Babayeva G.H., Karimova K.M, Babayev Z.M, Ismayilova X.M, Samedova T.A.
ULCERATIVE COLITIS AND CROHN'S DISEASE: BASICS OF IMMUNOPATHOGENESIS
Abstract: The review is devoted to the immunopathogenesis of ulcerative colitis and Crohn's disease, and the role of diagnostic and adaptive immunity in the pathogenesis of inflammatory bowel disease has been highlighted. The odds of cytokine status, TLR (toll-like receptors), NLR (nod-like receptors) and microbiota have been reported on the effects of ulcerative colitis and Crohn's disease on immunopatogenesis. The effects of immunopatogenesis on the clinical course of inflammatory bowel infections and basically the phenotypes of Crohn's disease have been explained. Information about the functional defects of the immune system's receptor device during inflammatory diseases of the intestine provides a basis for a new treatment strategy (target therapy). Only target therapeutic strategies can be used to normalize and correlate the relationship between the intestinal mucous membrane and the intestinal microflora.
Keywords: inflammatory bowel infections, ulcerative colitis, Crohn's disease, microbiota, basics of immunopathogesis
Mammadova N.Y., Afandiyeva M.T.
MEDICAL REHABILITATION OF GASTROESOPHAGEAL REFLUX DISEASE
Abstract: The presented article is devoted to the review of literature, methods of treatment of patients with gastroesophageal reflux disease (GERD) using mineral waters, physio- and balneotherapeutic factors, acupuncture. The standards of rendering medical care to patients with GERD using physio-balneotherapeutic factors and modern technologies of restorative medicine used in rehabilitation are presented.
Keywords: gastroesophageal reflux disease, sinusoidal modulated current, pulsed low-frequency electrotherapy, super high frequency electromagnetic field, acupuncture, naphthalene
Gasimzadeh G.S., Gasimov N.A.
RAY DIAGNOSIS OF THE ABDOMINAL COMPONENT OF COMBINED CRANIO-ABDOMINAL TRAUMA
Abstract: This article is devoted to one of the urgent problems of public health - radiation diagnosis of combined trauma. In order to determine the features of instrumental diagnostic monitoring of closed combined cranio- abdominal trauma it was analyzed a prospective examination of 230 patients with these injuries. Instrumental monitoring of the abdominal component of the injury consisted of ultrasound and spiral computed tomography of the abdominal organs. The questions of sensitivity, specificity and accuracy of these diagnostic techniques were studied.
Keywords: combined trauma, cranio-abdominal trauma, ultrasound, computed tomography, sensitivity, specificity
Javad-zadeh S.M., Nasirov P.R.
OPTIMIZATION OF CONTEMPORARY LABORATORY INVESTIGATIONS IN DIAGNOSTICS OF PROSTATE DISEASES IN PRIVATE HOSPITALS
Abstract: In modern urology and in international urological protocols, a number of physical, laboratory, radiological and minimally invasive instrumental examinations have been proposed for the diagnosis of prostate diseases. Nevertheless, overdiagnosis work up is not a rare case in management of prostate diseases. Unfortunately, such cases may occur during diagnosis for inflammatory prostate conditions, benign prostate hyperplasia (BPH) and more often on prostate cancer (PCa) diagnosis. Interestingly, overdiagnosis is common as among general practitioners, as well as among urologists. Growth of private hospitals and voluntary medical insurance companies (VMIC) in Azerbaijan Health care system over the past 15 years has increased overdiagnosis cases, affecting even more when commercial interests overcoming medical ones. This article discusses the experience of optimal diagnostic algorithm work up for early detection of prostate gland disease (2064 patients) in one private hospital over one year. Primarily based on international protocols and patient interest, the main purpose in development of such algorithmic recommendations is to meet the medical insurance company – patient – private hospital expectations during referral of patients from medical insurance to private hospitals.
Keywords: Lower urinary tract symptoms (LUTS), benign prostate hyperplasia (BPH), prostate cancer (PCa), bladder outflow obstruction (BOO), prostate specific antigen (PSA), voluntary medical insurance companies (VMIC), digital rectal examination (DRE), private hospitals, hyperdiagnostic
Figarov V.I., Javad-zadeh S.M., Figarov I.H., Ismayilov R.I.
EFFICACY AND COMPLICATIONS OF CONTACT LITHOTRIPSY
Abstract: The article presents information on the relevance of minimally invasive interventions in urolithiasis. 43 patients are indicated on the effectiveness of transurethral contact lithotripsy depending on the size of the stones, their location at various levels of the urinary tract, the severity of the inflammatory process, the state of the ureteral lumen, the dilatation of the upper urinary tract and the density of the stones. In 7% of patients, there is a need for open surgical intervention. The possible complications after using of transurethral lithotripsy and the conditions for their elimination are indicated.
Keywords: urolithiasis, extracorporeal shock wave lithotripsy, laser ureterolithotripsy, percutaneous nephrolithotripsy
Abstract: Ulcerative colitis and Crohn's disease continue to be an urgent problem of modern gastroenterology.
Aim. The purpose of the study was to create a system of criteria that allow real-time assessment of the severity of the clinical course of the disease in patients with inflammatory bowel disease (IBD) using parameters easily accessible to the patient, both psychologically and economically.
Materials and methods. In the period from August 2015 to November 2017 at the clinical base of the Therapy Department of Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, the Department of Inflammatory Bowel Diseases “MedEra Hospital” and the private medical center “Memorial Klinika”, were examined 101 patients with IBD, who had no history of complaints or complaints cerebrovascular, cardio- and neurovascular pathologies. The study included 87 patients, the age of patients 17-78 years (37.3±2.7); on the basis of sex 41 women and 46 men. The period of the disease before going to the specialist doctor was 1.9-7.2 years (3.9±1.1). 74 patients were examined on an outpatient basis and 13 people were on inpatient treatment. Diagnosis of the disease was established on the basis of generally accepted criteria in accordance with the recommendations of European Crohn's and Colitis Organization (ECCO). The severity of the disease was assessed by the criteria of Crohn's Disease Activity Index (CDAI) and Truelove-Witts Index (TW). Due to age differences in the standards of the studies, patients were divided into age groups: from 17 to 60 years (73 patients) and from 60 years and older (14 patients). Of the patients, 48 (55.1%) had Crohn's disease (CD) and 39 (44.8%) with ulcerative colitis (UC). In all the subjects, the content of homocysteine, high-sensitivity C-reactive protein (h/s-CRP), vitamin D and blood platelet count, albumin in urine, calprotectin in feces was determined. As control groups, 20 patients were diagnosed with "irritable bowel syndrome" (IBS) (group K1) and 15 volunteers (group K2), who did not present any complaints; control groups were comparable with the main age and gender. The degree of manifestation of changes in the studied indices of endothelial dysfunction was estimated as a percentage of the maximum permissible value of the norm (exceeding the upper limit or decreasing in comparison with the lower limit).
Results. In the general group of patients with IBD, 78 (89.6%) had elevated blood levels of homocysteine, 67 (77.0%) had h/s CRP, 66 (75.8%) had thrombocytosis, 87 100%) reduction of vitamin D content, 71 (81.6%) had albumin in urine. All 87 patients (100%) had an increased calprotectin content in the feces.
Conclusion. The obtained results completely confirm the important role of endothelial dysfunction in the pathogenesis of IBD. The use of the simple index in the calculation of the severity index of the clinical course of the disease in patients with IBD can be used to quickly objectify the patient's condition.
Keywords: endothelial dysfunction, homocysteine, albuminuria, high-sensitivity C-reactive protein (h/s-CRP), vitamin D, calprotectin, inflammatory bowel disease
Rashidova S.M., Bayramov I.P., Azizov N.V., Mammadov S.B., Garagozova A.A.
FEATURES OF SALMONELLA INFECTION IN CHILDREN OF EARLY AGE
Abstract: In the structure of acute intestinal infections in recent years there has been a significant increase in intestinal infections, specially salmonellas in infants. In preffered article we analyzed 484 medical histories from he Clinic children’s hospital №2 named after A. Garayev with diagnosis Salmonella Typhimurium during 2014-2015. 85% of the cases were found Salmonella Typhimurium and the course of diseases was sever in children under the age of 0-12 months.
Keywords: Salmonellosis, Salmonella Typhimurium, sepsis, toxicosis
Abstract: The study made it possible to establish that the pregnant women with helminth-protozoal invasion have a characteristic clinical picture. The clinical picture is characterized by the following forms: asymptomatic (on average 41.6±4.4%), chronic (25.6±3.9%),subacute (16.8±3.4%) and acute (16.0±3.4%). In the presence of pathogenic microflora, chlamydia and trichomonads in the urogenital tract, the frequency of the subacute and acute form of the course of helminth-protozoal invasion increases and ranges from 30.4±4.1% to 52.0±4.5% of cases, and this indicates the selection and use of the most effective medicinal preparations simultaneously for all the pathogenic ones identified.
Keywords: helminthiases, pregnancy, protozoal invasion
Gasimov N.A., Mirzaliyev I.B., Aliyev T.M., Akhundov E.C.
SURGICAL TREATMENT OF DECOMPENSATED CICATRICIAL – ULCERATIVE STENOSIS OF DUODENAL ULCER
Abstract: The experience of surgical treatment of 106 patients with decompensated cicatricial-ulcerative stenosis of duodenal ulcer. 76 patients completed radical duodenoplastics as the first stage of surgical treatment aimed at restoring motor-evacuation and secretory functions of the stomach. The second stage, after an additional survey was carried out selective proximal vagotomy, as antacid operation. 30 patients underwent resection of 2/3 of the stomach in versions. A comparative evaluation of methods of surgical treatment of decompensated cicatricial-ulcerative stenosis, analyzed early postoperative complications and long-term pathological syndromes.
Keywords: duodenal ulcer, decompensated cicatricial-ulcerative stenosis of duodenal ulcer, surgical treatment
Faradjeva S.S., Faradjeva N.A., Ahmadova Z.B.
INNOVATIVE TECHNOLOGIES IN METHODS OF DIAGNOSTICS OF OBESITY IN DIABETES MELLITUS TYPE 2
Abstract: The program centered survey may include the measurement of the thickness of skin folds of fat using this instrument is caliper, which is necessary as blood glucose meter, scales for the prevention of obesity in patients with diabetes mellitus 2 type. Was also noted the relevance of studying the influence of genetic predisposition of violations of carbohydrate-fat metabolism with the help of an innovative method - mass spectrometry. It turned out that the various ethnic groups of the Azerbaijani population from turning into fat accumulation of excess glucose more influenced by TA mutant variants of FTO c-46-23525 T>A and polymorphism CT heterozygote MC4R g.5641943.
Keywords: diabetes mellitus type 2 , obesity, innovative technologies
Abstract: This article reviews Azerbaijan physician rescue operation after civil plane crash in Nakhchivan airport (Nakhchivan Autonomous Republic) on 5 December 1995. Peculiarity of curative evacuation support during rescue operation after crash was nearness of large medical centres. This made possible carring immidiate evacuation and avoiding of few intermediate structural units deployment. Immidiate evacuation, intensive therapy and specialised high level treatment helped to keep mortality (3.7%) and disability level on minimum for high energy and velocity disaster despite of surge just about 50% polytrauma and combined trauma patients. Disaster’s data analysis demonstrates efficiency and expediency of external fixation apparatus application in surge capacity of polytrauma and combined trauma patients.
Keywords: curative evacuation support, emergency (disaster) medicine, external fixation apparatus osteosynthesis
Abstract: We examined 200 women with coronary heart disease (CHD), selected as a result of epidemiological and clinical examination. We studied the correlation between the relationship and the hormonal profile of the major risk factors (RF) of CHD in women. It was found that in women with CHD only hormones of progesterone (P) and testosterone (T) have correlations with overweight, namely a decrease in P and an increase in T lead to an increase in BMI. At the same time, in estradiol (E), no reliable relationships with other RF were detected in any parameter, i.e. level E does not directly affect any traditional RF in women with CHD.
Keywords: coronary heart disease, risk factors, women, sex hormones, correlation connections
Aliyev S.H., Bakhshaliyev Z.F.
UMBLICAL PILONIDAL SINUS – CLINIC COURSE AND TREATMENT
Abstract: A pilonidal sinus is a blind-end tract lined with granulation tissue, which leads to a cystic cavity lined with epithelial tissue. As the name suggests, this hair containing abscesses are usually found in the sacrococcygeal zone. However, they may also occasionally occur in the axilla, groin, inter-digital web, umbilicus, nose, inter-mammary areas, supra-pubic area, clitoris, prepuce, penis, occiput, and on the feet. Most cases of umbilical pilonidal sinus present as recurrent omphalitis with pain, suppuration and bleeding, or even as an umbilical mass. Pilonidal sinus typically affects young, hirsute men, often with poor personal hygiene. Obesity and sweating are other factors that facilitate hair entry in the epidermis. Sinus is caused by the friction of the skin at the base of the spine, leading to the embedding of the hair beneath the surface. The hair forms small cavities or pits, which are in truth, enlarged hair follicles, which go on to become sinuses. Bacteria and debris enter this sterile area, producing local inflammation and formation of pus-filled abscesses. In chronic condition, the sinus becomes an open cavity, constantly draining small amounts of fluid. In this case, we present a case report of umbilical pilonidal sinus in a young boy.
Keywords: umbilical, pilonidal sinus, pilonidal cyst, abscess
Shiraliyeva R.K., Aliyev R.R.
FEATURES OF BLOOD SUPPLY TO THE SPINAL CORD AND VASCULAR SYNDROMES
Abstract: The article is devoted to the peculiarities of the blood supply to the spinal cord. The article gives information on the topographic and anatomical structure of the main arteries involved in spinal cord vascularization. Syndromes appearing in the defeat of spinal cord vessels are discussed and their clinical significance is shown. The presented topic has great importance in clinical practice for neurologists, neurosurgeons and radiologists.
Keywords: spinal cord, vascularization, spinal arteries, vascular syndromes