Abstract: Listeriosis is an infectious disease from the group of zoonoses, caused by listeria, a variety of ways and factors of its transmission, polymorphism of clinical manifestations, high mortality. In 1940, Listeria monocytogenes was named in honor of the Aplician surgeon Lister, who proposed an antiseptic method. Listeriosis is found in all countries of the world. Among the dead, 147 are newborns; 24.8% of deaths occurred in children up to 2 months. and 34.9% for males older than 60 years. Given the complexity of the diagnosis and the severe course of the disease, the author analyzed contemporary literature.
Keywords: listeriosis, serological research, laboratory research, epidemiology
Isayev I.I., Mammadova R.R., Rafiyeva S.K., Mustafayeva Sh.S., Hajiyeva M.R., Khanmamedova S. Q., Mustafayeva A.I.
MODERN APPROACHES TO DIAGNOSTICS AND TREATMENT OF REACTIVE ARTHRITIS IN CHILDREN
Abstract: The article summarizes the etiology, clinical course, new views on the diagnosis and treatment of reactive arthritis, which has recently become widespread among children and many questions of which remain unresolved.
Keywords: children, reactive arthritis, clinic, treatment
Gasimova F.N., Ismaylova N.R., Mammadova R.N.
PSORIATIC ARTHRITIS AND COMORBID PATHOLOGY
Abstract: Psoriatic arthritis (PsA) is a multifactorial disease in which many organs and systems of the body can be involved in the pathological process. The article presents an overview of the modern literature data on the relationship of PsA with various comorbid conditions, the development of which is based on the common pathogenetic mechanisms. Changes in the cardiovascular, hepatobiliary, urinary, nervous systems, gastrointestinal tract and ophthalmopathy are discussed in detail.
Keywords: psoriatic arthritis, comorbidity, systemic manifestations
Kerimov A.Kh., Aliev A.R., Askerov N.A., Zeynalov F.A., Zeynalov R.S., S.Seyran kyzy, Huseynov T.E.
ONCOSURGERY FOR COECUM AND VERMIFORM CANCER
Abstract: The article presented by us is devoted to the analysis of the material of 97 patients with coecum and vermiform appendix cancer, who entered the abdominal department of the national center of oncology for the period 2005-2015 73 men, 24 women, the age of patients ranged from 38 to 78 years, from him 83% of cases, this pathology was revealed in patients 40-50 years old. Cancer of the coecum was established in 84, cancer of the appendix in 13 patients. Unfortunately, in 7 of them, the diagnosis was made after appendectomy operated in various general medical networks. Basically, in patients in 94, 3% of cases of the disease was accompanied by gastrointestinal (mainly small intestine) obstruction. Of the total, 96.2% of cases, patients underwent right-sided hemicolectomy with lymph dissection, after ileo-transverse anastomosis (side to side and end to side), if necessary, the liver was resected and, as a rule, in all cases, the abdominal cavity was drained. Based on the analysis of our own material, we obtained a number of conclusions.
Keywords: cancer, coecum, appendix, hemicolectomy, anastomosis
Abstract: Polycystic ovary syndrome is a frequent form of endocrinopathy, occurs in 5-10% of women of reproductive age. Aim. Study of content of anti-Mullerian hormone (AMH) in the blood and determining its role in the pathogenesis of PCOS. Methods. The study was conducted on 100 women of reproductive age with PCOS, who were randomized in two groups depending on the presence or absence of hypothyroidism. The first group included 60 patients with only PCOS; the second group – included 40 patients with PCOS and concomitant hypothyroidism, the control group included 20 practically healthy women of reproductive age without PCOS. All patient underwent determination of the content of AMH in blood serum by enzyme immunoassay. Results. The study of the results obtained showed that, the level of AMH in the blood of patient with PCOS (15.6±0.4 ng/ml) and in patient with PCOS and concomitant hypothyroidism (20.2±1.1 nq/ml) significantly (p<0.001) exceeded its content in the blood of women in the control group (8.2±2.1 nq/ml). As a result of our research, a high prevalence of the TG polymorphism of the AMH gene in women with PCOS and the association of this genotype with insulin resistance were found.
Keywords: polycystic ovary syndrome, anti-Mullerian hormone, correlation, polymorphism
Yagubova S.M., Akbarov E.Ch., Kerimova I.I.
PATHOMORPHOLOGICAL PICTURE OF THYROID GLAND CELLS DURING PERITONITIS OF STAPHYLOCOCCAL ORIGIN
Abstract: The article provides information about the possible pathological changes in the thyroid gland during peritonitis of staphylococcal origin. During the study, thyroid glands of adult male white rats weighing 180-200 grams were used and glands were investigated in different periods of the experiment – on the 2nd, 5th, 15th, and 30th days. Experimental staphylococcal peritonitis was modeled by injecting a solution of S. aureus culture into the peritoneal cavity at a concentration of 1x109 microbial cells/kg in a volume of 1 ml. The results of the study showed that from the early stage of the experiment, the development of edema in the stroma begins due to the insudation of plasma – increased pasmorrhagia as a result of damage to the vascular wall in the thyroid gland. This leads to colliquative necrosis of individual thyrocytes and desquamation of follicular cells. Towards the end of the experiment, there are gradual atrophic changes in the lobules, follicles, and thyrocytes of the gland, the interaction of small and large follicles in the parenchyma is disrupted, sclerotic changes develop in the stroma.
Keywords: staphylococcal infection, thyroid gland, thyrosites, follicles
Abstract: The purpose of this article was to study the problem of the quality of dispensary observation of children with various diseases in the children's polyclinic No. 13 in Baku during 2014-2019 years. Among children with newly diagnosed diseases in 2014, 31% of children were under dispensary observation, in 2015 and 2016 – 27%, and in the next 3 years – 35%, 38% and 30%, respectively. At the same time, there was a tendency towards a slight increase in dispensary observation from 49% in 2014 to 50% in 2019, demonstrated that in the structure of incidence the first place is occupied by diseases of the respiratory system, the second – eye diseases, the third – diseases of the nervous system, the fourth – diseases of the musculoskeletal system, and, finally, the last place – diseases of the digestive system. Diseases of the nervous system prevailed in the structure of morbidity among children registered by dispensary observation during the study. Eye diseases and diseases of the musculoskeletal system occupied the second place, in third place were diseases of the blood and hematopoietic organs, in last place were diseases of the respiratory system. It should be noted that this study does not allow us to unequivocally assess the activity of mandatory annual examination of young children. In this regard, in order to improve the system of mandatory annual examination, it is necessary to apply the methodology for examining the quality of dispensary work in children's outpatient clinics.
Keywords: mandatory annual examination of children, dispensary observation, structure of diseases, newly diagnosed disease
Shikhaliyev Y.Sh., Kazimova L.H., Huseynaliyeva V.N., Abbasova A.S., Gasimov I.A., Shikhlinskaya M.A.
THE IMPACT OF IMPROVING ANTI-TUBERCULOSIS MEASURES ON EPIDEMIOLOGICAL INDICATORS IN URBAN AND RURAL PRIMARY CARE
Abstract: In order to clarify the level of anti-tuberculosis measures in primary health care facilities in urban and rural areas, an analysis was carried out in the urban – Nasimi, Yasamal and rural Gobustan regions from 2011 to 2015, and the reasons for the epidemiological tension were clarified. A similar epidemiological analysis was carried out in 2016 on the basis of medical records of primary patients and report forms No. 8 "About Tuberculosis", approved by the State Statistical Committee. The groups at high risk of morbidity were: pensioners, housewives, migrants within the country, released from prison and not treated in prison hospitals, persons aged 19-24, people with diabetes mellitus. As a result, in urban and rural areas, compared to 2016, the proportion of focal tuberculosis among primary pulmonary tuberculosis increased 3.3 and 1.7 times, and the decay phase decreased 1.5 times. The intensive incidence rate of the local population in comparison with 2016 in the first two years of the survey increased by 21.9% and 30%, and in the third year it corresponded to the indicators of 2016. Among the general population it increased by 9.3% and 41.5%, and in the third year decreased by 3% compared to 2016. In rural areas, this indicator increased by 7.8% in the first year and decreased by 31.9% and 22.3% in the second and third years. The use of the accelerated molecular genetic detection method increases the efficiency of bacteriological examination in urban and rural areas by 16.5% and 33.3%, respectively. The success rate of treatment reaches 93.8% in urban areas and 93.7% in rural areas. Based on the results obtained, an algorithm was developed, the main components of which are sanitary prevention, identification of high-risk groups, examinations under strict control and the organization of treatment by decision of the central medical advisory commission.
Keywords: primary health care facilities, sanitary prophylaxis, risk groups, morbidity
Sadykhova F.A., Mutalibova N.F., Nasirova F.J., Bayramova Sh., Kozhevnikova D.A.
COMPARATIVE STUDY OF EXPERIMENTALLY OBTAINED AND NATIVE BIOFILMS FORMED FROM THE HUMAN BODY DURING CHRONIC INFECTION
Abstract: This article highlights the problem of bacterial biofilms once again. The effect of selected doses of X-rays on destructive cellular changes in the biofilm modeled from the culture of St.aureus was studied by the classical bacteriological method by counting colonies on yolk-salt agar. The data obtained made it possible to expand the understanding of the effect of X-rays on the multilayer structural organization of biofilms.
Keywords: biofilms, X-rays, electron microscopy
Kurbanova J.F., Adygezalova Ibadullayeva K.P.
CORRELATION OF ANTIBODIES AND THYROID HORMONES IN WOMEN OF FERTILE AGE WITH OLIGOMENORRHEA
Abstract: The article presents the results of assessing the levels of thyroid hormones and antibodies to thyroglobulin (AT-TG), thyroperoxidase (AT-TPO) and studying the relationship between them in women with oligomenorrhea. The study involved 103 women with oligomenorrhea (main group) and 50 women with a normal menstrual cycle (control group). The average age of the patients in the main and control groups was 31.39±6.05 and 30.52±5.92 years, respectively. Along with the generally accepted examination, TTH, T3, T4, antibodies to AT-TG and AT-TPO were determined in the blood. In women with oligomenorrhea, there was a slight increase in TTH, T3 and T4, and the T3/T4 ratio. The level of AT-TG and AT-TPO in women of the main group in comparison with the control group increased 3.5 times (p=0.024) and 7.1 times (p=0.003), respectively. Weak positive correlations were revealed between thyroid hormones and AT-TG and AT-TPO. The study confirmed that in women with oligomenorrhea, it is necessary to determine thyroid hormones and antibodies to thyroglobulin and thyroperoxidase.
Keywords: menstruation, women of fertile age, oligomenorrhea, thyroid gland, thyroid hormones, correlation
Abstract: The article provides information on risk factors and comparative features of quality of life in 409 patients with type 2 diabetes mellitus living in the capital and northern regions of Azerbaijan. Information on risk factors was obtained using the "ARIC" questionnaire, and body mass index and abdominal obesity were determined. It was found that among diabetics living in Baku, working, low and moderate alcohol consumption, mild malnutrition, grade II, III and abdominal obesity, low physical activity, subclinical anxiety, moderate and severe stress were observed more often. In the northern region, smoking, alcohol abuse, moderate to severe malnutrition, clinical anxiety and depression, and high levels of stress predominated, leading to a deterioration in the quality of life of patients in the region. Therefore, it is important to conduct regular screenings and strengthen preventive measures among type 2 diabetes mellitus patients, mainly in the northern region.
Keywords: type 2 diabetes mellitus, risk factors, quality of life
PANCREATIC MANIFESTATION IN INFLAMMATORY BOWEL DISEASES
Abstract: The problem of inflammatory bowel disease (IBD) continues to be one of the pressing issues of gastroenterology. Damage to the pancreas in this group of patients has many faces: from the elevation of pancreatic enzymes and exocrine insufficiency, acute, autoimmune and chronic pancreatitis to malignancy of the gland. Aim: to identify the frequency and nature of pancreatic lesions in patients with IBD. Material and methods. Between August 2015 and November 2019, 154 patients with IBD were examined; of these, 82 (53.2%) with Crohn's disease (CD) and 72 (46.7%) with ulcerative colitis (UC). Age of patients: 18-60 years (39.4±4.6). By gender: 81 (52.6%) women and 73 (47.4%) men. Disease period before going to a specialist doctor: 1.1–8.3 years (3.7±1.2). Patients were under dynamic observation for 6 to 32 months (14.4±5.7). Patients underwent a general clinical examination according to ECCO standards, taking into account the pancreatic lesion, the anti-lactoferrin İgG and İgG in the blood, fecal elastase in the feces were included in the examination plan. Patients underwent abdominal ultrasound, if necessary, pancreatic EUS, abdominal CT and MRI. Results. In 94 (61%) patients with abdominal ultrasound, changes in echogenicity were detected, in 21 (13.6%) patients - in the size of the main pancreatic duct; changes in ESM were found in 6 (3.89%) patients. Hyperamylasemia was detected in 9 (5.84%) patients; drug damage - in 34 (22%) patients (with azathioprine, sulfasalazine, metronidazole, steroids) and were more characteristic of the first weeks of therapy. Acute pancreatitis due to cholelithiasis was detected in 12 (7.79-14.63%) patients with CD. Autoimmune pancreatitis – in 8 (5.19%) patients, exocrine gland failure – in 42 (27.3%) patients with IBD. Conclusion. Pancreatic manifestations associated with IBD were characterized to a greater extent by exocrine insufficiency (27.3%) and drug lesions (22%), to a lesser extent by acute biliary (7.79%) and autoimmune pancreatitis (5.19%).
Keywords: inflammatory bowel disease, pancreatic damage, exocrine insufficiency, autoimmune pancreatitis
Jafarova G.S., Isayev J.I.
MORPHOLOGİCAL AND ANATOMİCAL FEATURES OF THE PLANT DRACOCEPHALUM AUSTRİACUM L.
Abstract: There are 4 species of Dracocephalum in the flora of Azerbaijan, of which D. austriacum is the most widespread. Macroscopic and microscopic analysis of the plant was carried out in the research work. The plant was collected around Gryz village of Guba region, in subalpine meadows, at an altitude of 1900 m above sea level: 41 ° 14'48.6 "N 48 ° 17'01.9" E. The stem consists of a single layer of pericyclic cells, the cells are thin-walled, forming a solid ring that is clearly visible in the periphery of the central cylinder. Differentiation of mesophyll into palisade and spongy parenchyma are observed in the leaf. There are also unicellular, bicellular, and capillary hairs, stomata is anomocytic-type. Different diagnostic features identified in the morphological and anatomical structure of the D. austriacum allow it to be distinguished from other plant species and to be determine the identity of the plant.
Keywords: Dracocephalum austriacum, macroscopic analysis, microscopic analysis, diagnostic features
Abstract: Intoduction. The issues of rational diagnosis and assessment of the condition of patients with inflammatory bowel diseases (IBD) remain relevant. Unfortunately, the methods used in diagnostics (endoscopy, X-ray, CT, MRI, ultrasound) do not allow to accurately determine the thickness of the intestinal wall with a targeted biopsy during a diagnostic study. This opportunity is provided by endosonography (endoscopic ultrasonography, EUS) - a method that combines the capabilities of endoscopy and ultrasound. The aim of the study – to evaluate, using EUS, the dependence of the severity of the condition on the thickness of the intestinal wall in patients with IBD. Materials and methods. A total of 90 patients with a morphologically confirmed diagnosis of IBD.All patients were additionally determined by highly sensitive "C" reactive protein (h/s CRP) in the blood, a fecal markercalprotectin and lactoferrin, intestinal EUS was performed. Results. In 71 (78.9%) patients with IBD, including 3 patients who were in the stage of clinical and endoscopic remission, the results of EUS revealed a thickening of the intestinal wall from 3.1 to 7.2 mm. The degree of thickening of the intestinal wall directly corresponded to the severity of the patient's condition (p˂0.05. The level of increase in the h/s CRP, lactoferrin and calprotectin is reliably associated with the severity of the patient's condition (p˂0.05). Conclusion. In patients with IBD, in 78.9% of cases, thickening of the intestinal wall remains, the severity of which corresponds to the severity of the condition. For patients with IBD it is advisable to periodically perform intestinal EUS with additional determination of h/s CRP in the blood and fecal marker lactoferrin.
Keywords: inflammatory bowel disease, endoscopic ultrasonography (EUS), intestinal wall thickness, calprotectin, lactoferrin, highly sensitive C-reactive protein
Eyubova U.A., Rahimova G.G., Bakhshiyev M.M.
STUDY OF THE INFLUENCE OF THE COMPLEX PHARMACOLOGICAL RESOURCE SACUBITRIL/VALSARTAN ON THE LEVEL OF NATRIURETIC HORMONE AND THE FREQUENCY OF DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE
Abstract: The article describes a study to investigate the possible relationship between the determination of the complex pharmacological agent saccubitrile/valsartan in patients with chronic heart failure and the level of B-type natriuretic peptide and the frequency of recurrent decompensation. For this purpose, a study was conducted on 64 patients with relevant chronic pathology. Each patient was tested for B-type natriuretic peptide levels before and 6 months after treatment, as well as cases of decompensation within 6 months. The study found that the complex pharmacological agent saccubitril/valsartan lowers the level of B-type natriuretic peptide more than other therapies. Causes a decrease in the frequency of decompensation.
Keywords: chronic heart failure, sacubitril/valsartan, B-type natriuretic peptide (BNP)