Quliyeva Z.M., Karimova K.M., Sadigov R.V., Hajiyeva G.K., Ahmadova L.M.
CRITERIA OF ACTIVATING PROCESSES OCCURRING IN THE STRUCTURE OF LYMPHOCYTES IN PATHOLOGY
Abstract: The article focuses on the characterization of lymphocytes during many pathological activating processes in the body. The lymphogram is characterized by criteria of activating processes: lymphocytosis, limfopeniya, apoptosis, premature condition, acquired immunity, spontaneous cytotoxicity, reactivity of the organism, infectious mononucleosis, lymphocytoma, centrofollicular lymphoma, chronic lymphoid cellosis. The increase in the size of the cell, the decrease in its nuclear-cytoplasmic ratio, the displacement of the nucleus to the periphery, the homogenization and enlightenment of the structure of chromatin, the increase in the basophilicity of the cytoplasm are clear criteria for the activation processes occurring in the lymphocyte. A group of Russian scientists divided four types of lymphocytes to characterize different degrees of activation: inactive lymphocytes; lymphocytes with cortical lymphocytes; lymphocytes of intermediate fraction; active lymphocytes. It has been revealed that the addition of micronutrients in lymphocytes during radiation can also occur in patients with active herpes infection, which indicates the damage to the genetic apparatus of the cell.
Keywords: lymphogram, immunity, infectious syndrome
Hajiyeva G.H., Hajiyev E.H., Hajiyeva G.K.
SARCOIDOSIS AND SARKOIDOSIS OF SPLEEN DESCRIPTION CLINICAL EVENTS
Abstract: The article presents information on sarcoidosis, including sarcoidosis of the spleen, its spread throughout the world and a description of clinical events. The examples given in the article lead to the following conclusions: removal of a damaged spleen often leads to remission. In the diagnosis of sarcoidosis, along with instrumental methods of ultrasound, MRI, biopsy, the following laboratory indicators are important: cytokines, alkaline phosphatase, lysozyme, calcium in blood and urine and angiotensin converting enzyme, etc. In splenomegaly, it is desirable to prescribe steroids, cytostatics and sarcoidosis since splenectomy is often fraught with complications.
Keywords: sarcoidosis, sarcoidosis of the spleen, splenectomy
Guliyev F.A., Ismayilova S.S., Guliyeva I.М., Aliyev R.R., Guliyeva N.M., Gahramanova D.I.
GENETIC-ENGINEERING BIOLOGICAL DRUGS AND THEIR ANALOGUES IN THE TREATMENT OF IMMUNE-INFLAMMATORY DISEASES
Abstract: The presented review of modern research is devoted to a new group of drugs that have been called genetic engineering biological products (GEBP). The article describes the characteristics, indications for use, as well as contraindications to the appointment of this group of drugs. The article also outlines the basic terms and concepts related to biosimilars, generics, and original drugs. A comparative characteristic between biosimilars, generics, and their originals is given. The main applications of biosimilars are considered.
Keywords: genetic engineering biological products (GEBP), biosimilars, generics, original drugs, biological agents
Kabirli V.Z., Hashimli R.M., Huseynov N.M., Afandiyev A.Z.
IMPACT ASSESSMENT OF SEPTOPLASTY ON THE ACOUSTIC PARAMETERS OF VOICE
Abstract: As a result of a septoplasty operation performed to eliminate the problem of nasal breathing, a change in the nasal cavity can affect the flow of the nose, the resistance, the resonance characteristic of intranasally formed sounds and ultimately, the voice quality. In total 27 patients with a diagnosis of nasal septal deviation and who underwent septoplasty a voice analysis was performed. Preoperative and on postoperative 30th day, acoustic analysis of voice was conducted for all patients. Recordings of /mana/ vowel were used to evaluate average fundamental frequency (F0), jitter, shimmer. F0, shimmer percent, jitter percent of two terms were compared. A statistically significant change was not observed in F0 (p=0.303), jitter (p=0.889), and shimmer (p=0.027) measured preoperatively and on postoperative day 30.
Keywords: Septoplasty, nasal breathing, acoustic analysis, acoustic features of voice, voice, jitter, shimmer
Abstract: Road traffic injuries are cause of 1,2 million death each year, it is main reason of death in age group from 15 till 29 y.o. Materials and Methods. Ministry of Health of Azerbaijan Republic purposeful curry out road traffic injuries prevention programms since 2006. Ministry of Health of Azerbaijan Republic and WHO сooperated for conducting Global Status Report on Road Safety - I, II, III and IV projects. Results and discussion. Decrease of mortality level despite grow of risk factors as country population and number of vehicles is one of the main indicator of carried programms efficiency. This programms have a purpose to reduce injuries according road traffic and develop emergency service.
Keywords: Global Status Report on Road Safety, road traffic injury, injury prevention
Suleymanov T.A., Shukurov C.Y.
SYNTHESIS AND INVESTIGATION OF BIOLOGICAL ACTIVITY OF DITHIOCARBAMATE DERIVATIVES
Abstract: Many literatures on dithiocarbamate derivatives have been collected and analyzed. As a result of the analysis, it was found that dithiocarbamates possess many chemical properties. Five substances containing fragments of dithiocarbamate and 4-piperidine-aniline, five substances containing fragments of dithiocarbamate and N-methylpiperazine-aniline and five substances containing fragments of dithiocarbamate and morpholine-aniline were synthesized, chemical structures of synthesized derivatives were determined by IR, NMR and Mass spectroscopy. The biological activity and toxicity of the synthesized derivatives were investigated. The antifungal activity of certain substances was established and was found activity of some compounds.
Keywords: dithiocarbamates, antifungal, Brine-shrimp lethality assay
O.S. Seyidbeyov, S.Z. Aliyev, R.M. Meybalizada
CHANGES IN PHYSICAL AND CHEMICAL INDICATORS OF SALIVA IN PATIENTS WITH SYALOSIS AGAINST DIABETES
Abstract: Diabetes is the most acute medical and social problem in all countries of the world. The prevalence of type 2 diabetes mellitus (type 2 diabetes) around the world has become a pandemic. A special group is represented by reactive-dystrophic diseases of the salivary glands - sialosis, developing against the background of the pathology of other human organs and systems. It is known from literary sources that, when diabetes occurs, the pH of the mixed saliva changes towards acidity with the development of local acidosis, and later, with a disease extension decompensation occurs with a persistent disruption of the acid-base balance in the oral cavity. The aim of our study is to evaluate the nature of the physicochemical parameters of saliva in the dynamics of basic and complex treatment. We examined 40 patients, divided into 2 groups according to the duration of disease of type 2 diabetes. Group 1 included patients with a duration of type 2 diabetes of less than 5 years (19 patients), and group number two with the duration of type 2 diabetes was more than 5 years (21 patients). The studies revealed changes in the physicochemical properties of saliva in patients with sialosis and type 2 diabetes. When carrying out complex treatment with enzyme therapy, the secretory activity of LF was restored. The viscosity of saliva decreased and the pH of the saliva changed in a neutral direction.
Keywords: diabetes mellitus, syalosis, enzyme therapy
Abstract: The article presents data on thrombotic complications and tendencies to latent hypercoagulation in patients with β-thalassemia and IDA. A total of 277 women with anemia (142 with β-thalassemia and 135 with IDA) were examined. "Tendency to increased thrombosis". It has been established that some patients with hereditary and acquired anemias have clinically pronounced thrombotic complications. About one third of patients with homozygous β-thalassemia and iron deficiency anemia, in whom no thrombotic complications have been identified, have a tendency to latent hypercoagulation, i.e. prethrombotic readiness of hemostasis. In patients with heterozygous β-thalassemia and in healthy women (blood donors), a tendency to latent hypercoagulation was not detected.
Keywords: β-thalassemia, iron-deficient anaemia, thrombotic complications latent hypercoagulation
Abstract: The goal is to assess the condition of newborns in pregnant women with pre-amplification associated with anemia. The study involved 122 pregnant women with preeclampsia and 122 pregnant women without preeclampsia (control group). Surveyed were divided into 3 groups: I group - mild (46 women); Group II - moderate severity (40 women); Group III - severe (36 women). Women conducted a comprehensive survey. Studies have shown that in pregnant women with preeclampsia and anemia compared with the control group, newborns with hypotrophy and prematurity were respectively 38.39% and 27.87%. Posthemorrhagic encephalopathy was observed in 12.5% of cases, hypoxic-traumatic disorders - in 13.39% of cases, intrauterine chronic hypoxia - in 33.04%, morphofunctional immaturity - in 38.39%, birth injury - in 3.57%, perinatal CNS damage - in 8.04%, aspiration syndrome - in 11.61%, respiratory failure syndrome - in 9.82% of cases. The high frequency of perinatal complications in pregnant women with preexlampsia and anemia indicates the relevance of prevention.
Keywords: pregnant women, preeclampsia, anemia, newborns, prematurity, malnutrition, hypoxia, perinatal complications
N.S.Aliaskerli, M.G.Aliyev, L.I.Rustamova, I.I.Erdogan
CLINICAL MANIFESTATIONS OF ACUTE CYTOMEGALOVIRUS INFECTION IN ADULTS
Abstract: The aim of investigation was to study the clinical manifestations of acute cytomegalovirus infection in adults. For this purpose, the 41 men have been serologically and molecular-biologically observed for acute cytomegalovirus infection. The middle age of men was 34.7 years old. It was detected that acute cytomegalovirus infection registrated in men mostly in 17-29 age group (45.0%). The acquiring acute cytomegalovirus infection in men flow in mainly as middle-heavy form and characterize of fever, lymphadenopathy and hepatomegaly.
Keywords: cytomegalovirus infection, adults, symptoms, diagnostics
Akparov I.K., Aliyev T.M.
COMPLICATIONS AFTER CLOSURE OF THE COLOSTOMY AND THEIR SURGICAL TREATMENT
Abstract: This interesting clinical case errors in diagnosis and treatment selection. Before the operation to close the stoma, the patient was not fully examined. The tumor is not diagnosed in time. In the end, the chosen surgical approach was wrong and the patient has not received full assistance. Observed dehiscence of anastomosis and formation of intestinal fistulas. Before the last operation, the patient made colonoscopy, but against infiltrations and fistulae was not possible to identify the tumor. The tumor was only discovered during surgery and removed.
Keywords: complications, surgical treatment, closure of colostomy
Gasimov N.A, Kazimov A.K.
CHRONIC ULCER OF DUODENUM COMPLICATED BY DECOMPENSATED PYLORODUODENAL STENOSIS
Abstract: Ulcer of the duodenal ulcer, its conservative and surgical treatment to this day are problems in the solution of which surgeons and gastroenterologists face great difficulties. In this regard, we analyzed and presented the clinical observation of a patient who, with a diagnosis of duodenal ulcer complicated by decompensated pyloroduodenal stenosis, severe form of type I diabetes mellitus, underwent a planned operation – resection of 2/3 of the stomach by the method of Bilroth-2. As can be seen, the patient suffered not treated for a long-time ulcer of the duodenum complicated by decompensated pyloroduodenal stenosis, as well as severe diabetes mellitus. As a result, the life of an elderly patient was threatened due to two serious illnesses. An analysis of the history of this disease suggests that the scope and timing of the operations can be considered expedient. Selected surgical tactics allowed saving the life of a patient with two serious illnesses. Carrying out radical surgery for elderly patients with severe diabetes is also possible. Thus, the analysis of the patient presented by us can have significance for clinical practice.
Keywords: duodenal ulcer, resection, pyloroduodenal stenosis, anastomosis, decompensation, conservative and surgical treatment
Babayeva G.H., Karimova К.М., Ismayilova K.М., Babayev Z.M., Ahmadzadeh Q.A.
MODERN ASPECTS OF NONINVASIVE LABORATORY DIAGNOSTICS IN GASTROINTESTINAL DISEASES
Abstract: Modern medicine tends to develop in the direction of changing the invasive methods to minimally invasive or non-invasive. The method of stool analysis (coprology) is traditionally used for assessment of condition of digestion. Recently in the arsenal of the laboratory, have emerged the new sensitive and informative methods, based on the study of feces. This article discusses the advantages of the specificity and high degree of reliability of the determination of some markers of non-invasive laboratory diagnostics, such as calprotectin, hemoglobin and transferrin. It was confirmed that using of modern sensitive methods allows to identify a number of diseases or infectious agents that cause diseases of the gastrointestinal tract for the analysis of stool non-invasive, affordable and easy for any patient.
Keywords: noninvasive diagnostic, fecal markers, inflammatory diseases of the intestine, fecal hemoglobin, calprotectin
Abstract: This article presents the clinical classification and modern diagnosis of rheumatoid arthritis. This classification helps practitioners in the correct establishment and formulation of the diagnosis. Modern diagnostics of rheumatoid arthritis is based not only on determining acute phase inflammatory parameters in the blood, but also on identifying highly sensitive and highly specific markers of rheumatoid arthritis, such as rheumatoid factor and anti-CCP (antibodies to cyclic citrulline peptide). Early diagnosis of rheumatoid arthritis is the main criterion for the correct treatment of this pathology.
Keywords: rheumatoid arthritis, clinical classification, diagnosis, autoimmune diseaseş