Quliyeva Z.M., Karimova K.M., Sаdıqov R.V., Hajıyeva G.K., Ahmadova L.M., Hajıyeva G.H.
LABORATORY SIGNS AND MAIN FACTORS OF PATHOGENESIS IN DIAGNOSIS OF ANEMIA OF CHRONIC DISEASES
Abstract: The data concerning the new important factors of the pathogenesis of anemia of chronic diseases in patients with AHP, which are acquired complications of many pathological processes, aggravating their course, are given. The role of erythropoie¬sis – stimulating agents and iron preparations in the treatment of pa¬tients with anemia of chronic diseases, in particular those complicating the course of a neoplastic, infectious, inflammatory, or autoimmune disease, is shown.
Keywords: chronic anemia, iron, hepcidin
Ahmadova Z.Q., Faradjeva N.A., Faradjeva S.S.
DIABETES MELLITUS TYPE 2 AND OBESITY AS A MULTIFACTORIAL DISEASES
Abstract: The review indicates the high prevalence of type 2 diabetes mellitus (DM2). As a chronic disease, there are earlier periods than others of disability and mortality. Data on the prevalence of DM2 in Azerbaijan are presented. Made a smooth transition to another problem of metabolic disorders – obesity as "epidemic of the century." The urgency of the problem of overweight in the world is emphasized. Genetic predisposition to these diseases and close connection of their pathogenetic mechanisms were noted.
Keywords: diabetes mellitus, obesity, risk factors
Abstract: Dermatitis (Periorbital dermatitis-PD) often occurs around the eyes, particularly in eyelids. The disease is widespread among the people aged more than 40. The patient suffering from dermatitis is mostly annoyed by dryness in eyelid, itching, pellicle and redness. The patients are also concerned about their esthetic. There are a lot of factors causing the disease. Taking into account contact of the area around the eyes with environment due to being open we can highlight significance of effect of allergic and irritating factors on formation of the disease. On the other hand, the fact that the disease is mainly observed in women indicates allergic factors (due to use of cosmetics). Besides, products we use every day (soap, shampoo, perfume etc.) can lead to this disease. Anyway, according to literature, allergic factors and contact irritating impact play significant role in formation of the disease. At the same time, those with atopic skin are vulnerable to this disease. Besides, other reasons causing PE include immunodeficiency, hereditary tendency, climate change, seasonal change, stress factor and hormonal disorder. Taking into account the role of allergic factor in development of disease, different allergic tests can be conducted referring to anamnestic data. By conducting these tests (patch test, Prick test) we can identify the substances causing allergy which is very important in treatment of the disease.
Keywords: periorbital dermatitis, allergic contact dermatitis, allergy
Gasymov N.A., Ibragimov F.I., Seyidov I.I., Mamedragimova S.А.
FEATURES OF THE MODERN SYSTEMIC VIEW ON THE TREATMENT OF PATIENTS WITH SEVERE COMBINED INJURIES
Abstract: During 2009-2015-th the City Clinical Hospital №3 received 1033 pa¬tients with severe combined injuries. For the analysis of the used therapeutic and diagnostic activities these patients were divided into 2 groups: the I group of patients received treatment in 2009-2010 was called a comparison group, II group of patients received treatment in 2011-2015-th the main group. When conducting treatment and diagnostic activities in the comparison group, traditional methods were used. The degree of severity of injuries in the patients of the main group was determined on the basis of the modern scale AIS (Abbreviated Injury Scale) and ISS (Injury Severity Scale) and these patients were assisted on the basis of the principle “damage control”. In order to clarify the surgical treatment tactics, we used the above-mentioned principles, taking into account the severity of the damage and the severity of the patients’ condition, which allowed us to form a new surgical treatment tactic, determined by the scale in cases where there are indications for step-by-step surgical intervention. This allowed us to reduce the mortality rate among the patients of the main group with combined cranio-cerebral trauma with the dominant of cranial lesions from 50.9±6% to 35.3±2.9%. This indicator in patients with combined abdominal injuries decreased to 27.8±3.6% compared to 44.7±8.1%, and in patients with chest injuries to 25.6±2.9% against 41.2±6.9% respectively, and these indicators are statistically correct with a high degree of completeness (p<0.001).
Keywords: severe combined injuries, polytrauma, skeletal system, lethality
Abstract: Diabetes mellitus (DM) is a spread pathology in all developed countries of the world and has more severe consequences. The aim of the study was assessing the dynamics of role of diabetes mellitus on sustained loss of working ability among population. Materials and methods. The data basis of the State Statistic Committee on initial disability was used as materials for the study, share disability per 100 000 persons on ages 0- 3, 4-7, 8-13, 14-17, 18-29, 30-35, 36 and elder was determined, their dynamics for 2012-2016 years was calculated by the method of the least squares’ method. Results. Frequency of initial disability caused by the diabetes mellitus among population changes between 15,0±0,4 – 26,9±0,50/0000. Main trend of disabilities was increasing and calculated by means of polynomial regression equations. Disability rate depending on age changed between 2,1±0,50/0000 and 50,3±1,10/0000 and calculated by means of polynomial regression equation. Share of diabetes mellitus among reasons of initial disability changes between 0,9-7,8%, average figure is 5,2-6,2%. Conclusion. Rate of initial disabilities caused by DM is less among child population (≤15,8±1,60/0000), is high among population of age 36 and older (≥ 27,6±0,80/0000). Dependence of initial disability on diabetes mellitus and dynamics by calendar years was calculated by accurate mathematical equations.
Keywords: diabetes mellitus, loss of working ability, disability
Huseynov N.M., Aslanov P.R., Afandiyev A.Z., Hashimli R.M.
FEATURES OF COCHLEAR IMPLANTATION IN THE POSTLINGUAL PERIOD
Abstract: Cochlear implantation has become a widely accepted intervention in the treatment of individuals with severe-to-profound sensorineural hearing loss. Cochlear implants are now accepted as a standard of care to optimize hearing and subsequent speech development in children and adults with deafness. But cochlear implantation affects not only hearing abilities, speech perception and speech production; it also has an outstanding impact on the social life, activities and self-esteem of each patient. Under the supervision there were 5 patients who underwent cochlear implantation according to the traditional method with transmastoid access to the cochlea and the introduction of electrodes through the cochleostoma. Evaluation of the effectiveness and monitoring of patients after cochlear implantation were carried out within 3 months from the beginning of the hearing-speech rehabilitation. Surgery was performed according to traditional posterior tympanotomy and cochleostomy for cochlear implant electrode insertion for all observed patients. The study was conducted in two stages: before speech processor’s activation and 3 months later. Pure tone free field audiometry was performed to each patient to assess the efficiency of cochlear implantation in dynamics. The aim of the study was also to evaluate quality of life with severe to profound sensorineural hearing loss after cochlear implantation. Each patient underwent questioning with the Azerbaijani version of 36 Item Short Form Health Survey (SF-36). SF-36 is a set of generic, coherent, and easily administered quality-of-life measures. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Our results demonstrate that cochlear implantation in post-lingual period consistently improved quality of life and enhance the efficiency of audiologic rehabilitation.
Keywords: cochlear implantation, speech processor, pure tone free field audiometry, speech audiometry, quality of life
Huseynov E.Y., Huseynova T.T.
DIAGNOSTICS AND TREATMENT OF NEUROGENIC BLADDER DYSFUNCTION
Abstract: Neurogenic dysfunction of bladder often causes severe acute reflux and reflux-nephropathy. In this study radioisotope and ultrasound doppler investigations were used for early diagnosis of nephrosclerosis. Treatment of neurogenic dysfunction of the urinary tract was performed by the therapy of oxybutynin hydrochloride. We observed 115 cases of severe urinary flow in 115 children aged 3 to 14 years. In ultrasound doppler mapping of the renal arteries, the resistance index increased depending on the degree of uric acid refraction. As a result, the effective volume of oxybutynin hydrochloride increased, and the amplitude and deterioration of irregular detrusor accumulation decreased.
Keywords: bladder, neurogenic disfunction, radioisotope investigation, ultrasound doppler examination, oxybutynin hydrochloride
Ismayilova G.E., Aliyeva T.T., Mustafayeva S.A.
FREQUENCY OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE 2
Abstract: The purpose of the study was to determine the frequency of occurrence of chronic kidney disease in patients suffering from diabetes mellitus during the routine of outpatient reception of the endocrinologist. In final research group were included 117 patients with diabetes mellitus, meeting the criteria included in the research. Patients were studied the research of microalbuminuria, proteinuria, creatinine, determining of the glomerular filtration rate according to the equations SKD-EPI. The stages of chronic kidney disease were determined according to the recommendations presented by the National Kidney Foundation. The Chronic Kidney Disease in a routine setting has been identified in 100 out of 117 patients-diabetics and so the frequency of occurrence is 85.5% in 14.5% of the patients included in the researches the disease wasn’t determined. The difference in the frequency of occurrence of this disease and its absence was 71.0% of 95% Cl (confidence interval) from 60.383 to 78.4245. The findings suggested high frequency of occurrence of Chronic Kidney diseases and may be suggesting indicative of a high prevalence of this disease among the diabetics and emphasize the need for the real analysis of the situation.
Keywords: diabetes mellitus type 2, chronic kidney disease, glomerular filtration rate
Shiraliyeva R.K., Mammadova N.O., Hasanov R.L., Aliyev R.R.
CLINICAL FEATURES OF STROKE IN YOUNG WOMEN ASSOCIATED WITH PREGNANCY
Abstract: Pregnancy, childbirth and the early postpartum period are periods requiring special attention in terms of the development of cerebral circulation disorders. The study examined the risk factors, etiology, and some issues of the clinical course of strokes chronologically related to pregnancy. The main group of the study consisted of patients with stroke, chronologically associated with pregnancy, the comparison group – non-pregnancy-related young women. It was revealed that in the group with stroke related to pregnancy, the estimated risk factors, etiology and clinical features of the disease differ from those not related to pregnancy.
Keywords: pregnancy, young women, stroke
Abstract: The goal is to determine the concentration of manganese (Mn), iron (Fe) and magnesium (Mg) in the blood and the correlation relationship between them in patients with prehypertension. The total amount of 77 patients with prehypertension (HNBP) and asthenic disorders (main group), 50 patients with prehypertension (HNBP) and without asthenic disorders (comparison group) and 20 healthy individuals (control group) were examined. Determination of the concentration of magnesium, iron andmanganese ions in the serum was carried out by the X-Ray fluorescence spectrometric method. The concentration of Mg in comparison with the control is statistically significantly reduced (by 30.8%) in patients of the main group. In the comparison group, the Mg level decreased by 20.9% relative to the control. The average serum Fe concentration in patients of the main group was statistically significantly lower compared with the comparison and control groups, respectively 2.2 times and 4.7 times. The average concentration of Mn in the blood in the main group was lower than in the comparison group 6.2 times and lower than in the control group 8.1 times. Changes in the level of serum elements and interelemental bonds in patients with HNBP and patients with HNBP with asthenia can be used as a prognostic tool for diagnosing this disease.
Keywords: prehypertension, asthenia, arterial hypertension, macro- and microelements, correlation
Hajiyeva R.S., Musayeva M.S., Mahmudbekova Z.F.
CYTOKINE PROFILE IN THE PUERPERAS AND ITS ASSOCIATION WITH POSTPARTUM COMPLICATIONS
Abstract: The aim of this study was to determine the levels of cytokines in puerperas in case of urgent childbirth and to study the relationship between changes in cytokines and postpartum complications. 57 puerperas with postpartum complications after urgent delivery were examined, the average age was 25.8±1.44 years (main group). Control group - 20 women of the same age (mean age - 24.9±2.08 years) with urgent deliveries without postpartum infectious complications. The determination of cytokines IL-1α, IL-6, IL-8, TNF-α, IL-4 and IL-10 was carried out in the blood by ELISA on day 4-5 after delivery. On average, the levels of IL-1α, IL-6, IL-8 and TNF-α in puerperas with postpartum complication were statistically significantly higher than control ones by 2.2 times (p<0.05), 2.3 (p<0.05), 5.8 (p<0.001) and 2.8 times (p<0.01), respectively. The average IL-4 content in women of the main group was 2.0 times higher (p<0.05) than in the control group, and IL-10 was 1.8 times lower (p<0.05) lower. For all complications of the postpartum period, an imbalance of pro- and anti-inflammatory cytokines was noted, and more pronounced changes were detected in IL-8 blood. The determination of IL-8 and its elevated serum level can be used as a nonspecific marker for predicting postpartum complications.
Keywords: puerperas, postpartum complications, cytokines, endometritis
Abstract: The purpose of the study was assessing the role of the family physician in the provision of treatment and diagnostic assistance to the population with visual illness. Materials of the study. Medical documentation of ophthalmologic patients applying to policlinics. Methods. Method of expert assessment; function and competitiveness balancing and statistical analysis methods. Results. It was determined that, share of eye diseases per 1000 person is 5.1±0.2 diseases of eyelids, 14.1±0.2 – conjunctiva, 15.3±0.3 crystalline disease, 52.0±0.5 refraction violation. Average quantity of visits to ophthalmologist are 17.85; 26.79; 21.42; 93.60. According to expert reviews 6.25; 11.15; 5.30; 38.0 (per 1000 persons) of these applications can be satisfied by ophthalmologist. Conclusion. Within the scope of the occupational competence and functions considered for the family doctor, the doctor can provide 79.4 per 1000 population with health care service of ophthalmologists.
Keywords: the role of family doctor, treatment-diagnostics service, eye diseases
MODERN CHARACTERISTICS OF THE RISK OF ABORTION
Abstract: The article studies the problems of the threat of premature pregnancy and reveals its prevalence, causes and outcomes in different terms of gestation. The risk factors for miscarriage are characterized, statistically significant markers and their prognostic value are determined. The tactics of managing pregnant women with regard to the role of risk factors is substantiated.
Keywords: gestation, abortion, early miscarriage, childbirth, risk factors
Sultanova S.S., Gasimova F.N.
MODERN TREATMENT OF RHEUMATOID ARTHRITIS
Abstract: This article provides practitioners with the basic principles of modern rheumatoid arthritis treatment according to the “treat to target” strategy. Attention is focused on the use of basic anti-inflammatory drugs, as the first line in the treatment of rheumatoid arthritis. Information is also provided on genetic engineering biologicals used in modern rheumatoid arthritis therapy.
Keywords: rheumatoid arthritis, modern treatment, basic therapy, genetically engineered biological preparations
Abstract: This article presents modern clinical classifications and the basics of diagnosis and differential diagnosis of Crohn's disease. Currently, there are no highly specific markers for laboratory diagnosis of Crohn's disease, and the clinical course is sometimes very similar to ulcerative colitis, as a result of which there are certain difficulties in the verification, diagnosis and differential diagnosis of this diseases. The proposed principles of diagnosis and differential diagnosis should help the practitioner in the formation and diagnosis of Crohn's disease. Timely diagnosis of Crohn's disease is not only the key to proper treatment, but also allows you to adequately assess the many severe complications that are observed in the course of Crohn's disease.
Keywords: Crohn's disease, classification, diagnosis, differential diagnosis, extra-intestinal manifestations