ABSTRACT
Nodular lymphoid hyperplasia of the gastrointestinal tract is characterized by the presence of many small nodules, usually 2 to 10 mm in diameter, located more frequently in the small intestine, stomach, colon, or rectum. The pathogenesis is largely unknown, and the occurrence is possible in all age groups, quite common in children, and may affect adults with or without immunodeficiency. In some cases, patients may have comorbidities, namely common variable immunodeficiency, selective IgA deficiency, Giardia intestinalis, celiac disease, Helicobacter pylori, and less often human immunodeficiency virus. Recently, data have appeared on the detection of nodular lymphoid hyperplasia in patients who have undergone COVID-19. Nodular lymphoid hyperplasia is usually asymptomatic but can cause a variety of gastrointestinal symptoms such as abdominal pain, chronic diarrhea, bleeding, or ileus. Diagnosis is by endoscopy or barium contrast and must be confirmed by pathological findings. Nodular lymphoid hyperplasia is a risk factor for both intestinal and, very rarely, extraintestinal lymphoma.
Keywords: nodular lymphoid hyperplasia, gastrointestinal tract, endoscopy, common variable immunodeficiency, selective IgA deficiency, Giardia intestinalis, celiac disease, Helicobacter pylori

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REFERENCES

1. Albuquerque А. Nodular lymphoid hyperplasia in the gastrointestinal tract in adult patients: A review // World J Gastrointest Endosc. 2014 Nov 16; 6(11): 534 540. doi: 10.4253/wjge.v6.i11.534
2. Elkholy Sh., Mogawer Sh., Farag A. Nodular lymphoid hyperplasia of the gastrointestinal tract: a comprehensive review // Acta Gastro-Enterologica Belgica. 2017, 80, 405-410.
3. Rubio-Tapia A, Hernández-Calleros J, Trinidad-Hernández S, Uscanga L. Clinical characteristics of a group of adults with nodular lymphoid hyperplasia: a single center experience // World J Gastroenterol., 2006;12:1945-1948. 
4. Baran B, Gulluoglu M, Akyuz F. Nodular lymphoid hyperplasia of duodenum caused by giardiasis // Clin Gastroenterol Hepatol., 2013;11:A22.
5. Schwartz DC, Cole CE, Sun Y, Jacoby RF. Diffuse nodular lymphoid hyperplasia of the colon: polyposis syndrome or normal variant? // Gastrointest Endosc., 2003;58:630-632.
6. Iacono G, Ravelli A, Di Prima L, Scalici C, et al. Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity // Clin Gastroenterol Hepatol., 2007;5:361-366.
7. Kiefte-de Jong JC, Escher JC, Arends LR, Jaddoe VW, et al. Infant nutritional factors and functional constipation in childhood: the Generation R study // Am J Gastroenterol., 2010; 105:940-945.
8. Tokuhara D, Watanabe K, Okano Y, Tada A, Yamato K, et al. Wireless capsule endoscopy in pediatric patients: the first series from Japan //J Gastroenterol., 2010;45:683-691.
9. Ward EM, Wolfsen HC. Review article: the non-inherited gastrointestinal polyposis syndromes // Aliment Pharmacol Ther., 2002;16:333-342.
10. Khuroo MS, Khuroo NS. Diffuse duodenal nodular lymphoid hyperplasia: a large cohort of patients etiologically related to Helicobacter pylori infection // BMC Gastroenterol., 2011;11:36.
11. Razafimahefa, V.J., Razafindrafara, H.E., Rabarison, M.R. et al. Nodular Lymphoid Hyperplasia of the Colon in an Adult Patient after Covid-19 Infection: A Case Report and Literature Review // Open Journal of Pathology (2023), 13, 1-8. https://doi.org/10.4236/ojpathology.2023.131001).
12. Qanneta R., Feliu-Masgoret M., García-Pardoetal G. Reactive ileal lymphoid hyperplasia related to SARS-CoV-2 infection as a unique clinical feature resembling Crohn’s disease // Revista de Gastroenterología de México. 2022. RGMXEN-855; No. of Pages 2. DOI: 10.1016/j.rgmxen. 2022.07. 010
13. Luzi G, Zullo A, Iebba F, Rinaldi V, et al. Duodenal pathology and clinical-immunological implications in common variable immunodeficiency patients // Am J Gastroenterol., 2003;98:118-121.
14. Atarod L, Raissi A, Aghamohammadi A, Farhoudi A, et al. A review of gastrointestinal disorders in patients with primary antibody immunodeficiencies during a 10-year period (1990-2000), in children hospital medical center // Iran J Allergy Asthma Immunol., 2003;2:75-79.
15. Khodadad A, Aghamohammadi A, Parvaneh N, Rezaei N, et al. Gastrointestinal manifestations in patients with common variable immunodeficiency // Dig Dis Sci., 2007; 52:2977-2983.
16. Said-Criado I, Gil-Aguado A. Nodular lymphoid hyperplasia in common variable immunodeficiency // Lancet., 2014;383:e2.
17. Postgate A, Despott E, Talbot I, Phillips R, et al. An unusual cause of diarrhea: diffuse intestinal nodular lymphoid hyperplasia in association with selective immunoglobulin A deficiency (with video) // Gastrointest Endosc., 2009;70:168-19; discussion 169.
18. Piaścik M, Rydzewska G, Pawlik M, Milewski J, et al. Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract in patient with selective immunoglobulin A deficiency and sarcoid-like syndrome--case report // Adv Med Sci., 2007;52:296-300.
19. Joo M, Shim SH, Chang SH, Kim H, Chi JG, Kim NH. Nodular lymphoid hyperplasia and histologic changes mimicking celiac disease, collagenous sprue, and lymphocytic colitis in a patient with selective IgA deficiency // Pathol Res Pract., 2009;205:876-880.
20. Agarwal S, Mayer L. Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency // Clin Gastroenterol Hepatol., 2013;11:1050-1063.
21. Olmez S, Aslan M, Yavuz A, Bulut G, Dulger AC. Diffuse nodular lymphoid hyperplasia of the small bowel associated with common variable immunodeficiency and giardiasis: a rare case report // Wien Klin Wochenschr., 2014;126:294-297.
22. de Weerth A, Gocht A, Seewald S, Brand B, et al. Duodenal nodular lymphoid hyperplasia caused by giardiasis infection in a patient who is immunodeficient // Gastrointest Endosc., 2002;55:605-607.
23. Onbaşi K, Günşar F, Sin AZ, Ardeniz O, Kokuludağ A, Sebik F. Common variable immunodeficiency (CVID) presenting with malabsorption due to giardiasis // Turk J Gastroenterol., 2005;16:111-113.
24. Monsanto P, Lérias C, Almeida N, Lopes S, et al. Intestinal nodular lymphoid hyperplasia and extraintestinal lymphoma--a rare association // Acta Gastroenterol Belg., 2012;75:260-262.
25. Garg V, Lipka S, Rizvon K, Singh J, et al. Diffuse nodular lymphoid hyperplasia of intestine in selective IgG 2 subclass deficiency, autoimmune thyroiditis, and autoimmune hemolytic anemia: case report and literature review // J Gastrointestin Liver Dis., 2012;21:431-434.
26. Chandra S. Benign nodular lymphoid hyperplasia of colon: a report of two cases // Indian J Gastroenterol., 2003;22:145-146.
27. Shuhaiber J, Jennings L, Berger R. Nodular lymphoid hyperplasia: a cause for obscure massive gastrointestinal bleeding // J Pediatr Surg., 2005;40:E17-E19.
28. Ersoy E, Gündoğdu H, Uğraş NS, Aktimur R. A case of diffuse nodular lymphoid hyperplasia // Turk J Gastroenterol., 2008;19:268-270.
29. Molaei M, Kaboli A, Fathi AM, Mashayekhi R, et al. Nodular lymphoid hyperplasia in common variable immunodeficiency syndrome mimicking familial adenomatous polyposis on endoscopy // Indian J Pathol Microbiol., 2009;52:530-533.
30. Bayraktar Y, Ersoy O, Sokmensuer C. The findings of capsule endoscopy in patients with common variable immunodeficiency syndrome // Hepatogastroenterology, 2007;54:1034-1037.
31. Tomita S, Kojima M, Imura J, Ueda Y, et al. Diffuse nodular lymphoid hyperplasia of the large bowel without hypogammaglobulinemia or malabsorption syndrome: a case report and literature review // Int J Surg Pathol., 2002;10:297-302.
32. Yoshino T, Miyake K, Ichimura K, Mannami T, et al. Increased incidence of follicular lymphoma in the duodenum //Am J Surg Pathol., 2000;24:688-693.
33. Jeon JY, Lim SG, Kim JH, Lee KM, et al. Nodular lymphoid hyperplasia of the stomach in a patient with multiple submucosal tumors // Blood Res., 2013;48:287-291.
34. Jonsson OT, Birgisson S, Reykdal S. Resolution of nodular lymphoid hyperplasia of the gastrointestinal tract following chemotherapy for extraintestinal lymphoma // Dig Dis Sci., 2002;47:2463-2465.