РЕЗЮМЕ
Тромбоз вен – очень распространенное и финансово сложное заболевание. Тромбоз глубоких вен может вызвать необратимое повреждение венозной системы и привести к отекам, язвам, гангрене и другим симптомам в пораженном органе. Кроме того, более половины легочных эмболий вызваны венозным тромбозом, который является самой серьезной причиной смерти у пациентов с ишемической болезнью сердца и инсультом. Похоже, что тромбоз глубоких вен стал серьезным заболеванием, влияющим на здоровье человека. В последние годы все большее число исследований приводит к убеждению, что воспалительные реакции вызывают венозный тромбоз. При этом транскрипционный фактор NF-κb является центральным медиатором воспаления, а сигнальный путь NF-κb может регулировать провоспалительный и коагуляционный ответ. Поэтому изучение и использование этого механизма может помочь найти новое решение для профилактики и лечения тромбоза.
Keywords: тромбоз, сигнальный путь NF-κB, воспаление, TNF-α, IL-6, фактор транскрипции, VCAM

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ЛИТЕРАТУРА

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