SUMMARY
Uterine fibroids remain one of the most common benign tumors of the female reproductive system, associated with a high frequency of reproductive disorders, anemia syndrome, and the need for surgical intervention. Modern approaches to their diagnosis and treatment are undergoing significant changes in the context of the rapid development of digital technologies. The integration of artificial intelligence into clinical practice for uterine fibroids is considered a promising direction in the development of evidence-based medicine, providing improved diagnostic accuracy, reduced number of unnecessary interventions, and enhanced quality of life for patients.
Keywords: uterine fibroids; artificial intelligence; diagnostics; personalized therapy; prediction; evidence-based medicine

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REFERENCES

1. ACOG. Management of symptomatic uterine leiomyomas // Practice Bulletin No. 228. Obstet Gynecol. 2021;137(6):e100-e115. doi:10.1097/AOG.0000000000004401
2. Al-Hendy A, Myers ER, Stewart EA. Uterine fibroids: burden and unmet medical need // Semin Reprod Med. 2022;40(3):187-197. doi:10.1055/s-0042-1751123.
3. Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma by age 50: ultrasound evidence // Am J Obstet Gynecol. 2003;188(1):100-107. doi:10.1067/mob.2003.99.
4. Baird DD, Harmon QE, Laughlin-Tommaso SK, et al. Prospective ultrasound-based cohort of young African-American women: fibroid development in early reproductive years // Am J Obstet Gynecol. 2020;222(4):S890-S891. doi:10.1016/j.ajog.2020.02.043.
5. Brandão M, et al. A comprehensive review of artificial intelligence in obstetrics and gynecology imaging // J Clin Med. 2024;13(4):1061. doi:10.3390/jcm13041061.
6. Bulun SE, Yildiz S, Adli M, Taylor HS. Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction // Semin Reprod Med. 2021;39(2):121-130. doi:10.1055/s-0040-1715895.
7. Di Spiezio Sardo A, et al. The FIGO classification of uterine fibroids: an update // Int J Gynaecol Obstet. 2019;146(1):1-6. doi:10.1002/ijgo.12766.
8. Donnez J, Dolmans MM. Uterine fibroid management: from the present to the future // Hum Reprod Update. 2020;26(6):665-686. doi:10.1093/humupd/dmaa017
9. Favilli A, et al. FIGO type 3 leiomyomas and infertility: physiopathology and new perspectives // Int J Gynaecol Obstet. 2024;164(3):685-694. doi:10.1002/ijgo.15260
10. FIGO Committee on Gynecologic Oncology. Revisions to the FIGO classification of uterine leiomyomas // Int J Gynaecol Obstet. 2018;143(3):393-398. doi:10.1002/ijgo.12624.
11. Giuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids // Int J Gynaecol Obstet. 2020;149(1):3-9. doi:10.1002/ijgo.13102.
12. Huo T, Lin Q, Wang X, et al. AI-aided method to detect uterine fibroids in ultrasound images // Sci Rep. 2023;13:320. doi:10.1038/s41598-022-26696-2.
13. ISGE (Loddo A, Djokovic D, et al.). Hysteroscopic myomectomy: guidelines of the International Society for Gynecologic Endoscopy // Eur J Obstet Gynecol Reprod Biol. 2022;268:121-128. doi:10.1016/j.ejogrb.2021.11.434.
14. Li B, Liu X, Peng J, et al. Global epidemiological characteristics of uterine fibroids // Arch Med Sci. 2023;19(5):1288-1298. doi:10.5114/aoms/171786.
15. Liu F, Zhang Y, et al. AI-guided MRI instance segmentation to optimize laparoscopic myomectomy // Front Oncol. 2025;15:1549803. doi:10.3389/fonc.2025.1549803
16. Lou Z, Wang X, Zuo J, et al. Global burden of uterine fibroids, 1990-2019: age-period-cohort analysis // BMC Public Health. 2023;23:1656. doi:10.1186/s12889-023-15765-x.
17. Mehine M, Kaasinen E, Mäkinen N, et al. Integrated data analysis reveals genetic/epigenetic leiomyoma subtypes // Nat Commun. 2019; 10:415. doi:10.1038/s41467-019-08307-6.
18. Munro MG, Critchley HOD, Fraser IS; FIGO Working Group. PALM-COEIN classification for causes of AUB // Int J Gynaecol Obstet. 2011;113(1):3-13. doi:10.1016/j.ijgo.2010.11.011.
19. NICE. Heavy menstrual bleeding: assessment and management (NG88). London: NICE; 2018 (updates 2021).
20. Raffone A, Raimondo D, Neola D, et al. Diagnostic accuracy of MRI to differentiate leiomyomas vs sarcomas: systematic review & meta-analysis // Int J Gynaecol Obstet. 2024;165(1):22-33. doi:10.1002/ijgo.15136.
21. Salehi AM, Farhadian M, et al. Environmental risk factors related to uterine leiomyoma: meta-analysis // Environ Res. 2023;214:113786. doi:10.1016/j.envres.2022.113786.
22. Saridogan E, Walker A, et al. (ESGE Working Group). ESGE Good Practice Recommendations on surgical techniques for removal of fibroids—Part 1: abdominal routes // Facts Views Vis Obgyn. 2024;16(4):383-397.
23. Sefah N, Azanu WK, Ampong JA, et al. Uterine fibroids: causes, impact, treatment and a lens to Africa. PLoS One. 2023;18(1):e0279111. doi:10.1371/journal.pone.0279111.
24. Shrestha P, Wright D, Kumar V, et al. A systematic review on the use of artificial intelligence in gynecologic imaging // Gynecol Oncol. 2022;166(1):38-52. doi:10.1016/j.ygyno.2022.07.024.
25. Somigliana E, Busnelli A, Vercellini P. Fibroids and natural fertility: a systematic review and meta-analysis // Best Pract Res Clin Obstet Gynaecol. 2021; 81:61-74. doi:10.1016/j.bpobgyn.2021.11.008.
26. StatPearls (Schwartz SM, Catherino WH). Uterine Leiomyomata // StatPearls Publishing; 2024.
27. Stewart EA, Laughlin-Tommaso SK, Catherino WH, et al. Uterine fibroids // Nat Rev Dis Primers. 2016; 2:16043. doi:10.1038/nrdp.2016.43.
28. Tinelli A, Morciano A, Sparic R, et al. Artificial intelligence and uterine fibroids: a useful combination for diagnosis and treatment // J Clin Med. 2025;14(10):3454. doi:10.3390/jcm14103454.
29. Tu W, Bhosale P, Iyer R, et al. Smooth muscle tumors of the uterus at MRI: key features and degenerative changes // Radiographics. 2023;43(3):e220161. doi:10.1148/rg.220161.
30. Vilos GA, Allaire C, Laberge PY, et al. The management of uterine leiomyomas // J Obstet Gynaecol Can. 2022;44(5):549-563. doi:10.1016/j.jogc.2021.12.003.
31. Vilos GA, Laberge PY, et al. Management of uterine leiomyomas (guideline) // J Obstet Gynaecol Can. 2022;44(5):549-563. doi:10.1016/j.jogc.2021.12.003.
32. Yang Q, Wu M, Wang D. Comprehensive review of uterine fibroids // Endocr Rev. 2022;43(4):678-713. doi:10.1210/endrev/bnac014.