SUMMARY
The study examined changes in the amount of immunoglobulins (Ig), as well as specific and nonspecific cells that provide the immune response, in the blood of rats due to toxic stress caused by lead acetate. It has been established that the state of toxic stress in the body changes the amount of immunoglobulins, as well as specific and nonspecific cells that provide the immune response in various directions. Depending on the duration of toxicity, changes in the number of immune markers in the blood become more pronounced, and the number of immunoglobulins significantly decreases on the 21st day of the experiment. After the exposure to toxic stress, the immune activity changes in the released group, and these changes do not normalize. Therefore, it is important to conduct research towards developing ways to correct toxic stress caused by intense environmental pollution.
Keywords: extreme situation, stress, heavy metal, monoamine, hormone, immunoreactivity

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