SUMMARY
This study examines the determination of the odds ratio of detecting micro- and macroprolactinomas according to the level of hyperprolactinaemia. Purpose. To determine the odds ratio for detection of microprolactinoma and macroprolactinoma depending on the level of hyperprolactinaemia. Material and methods. 139 patients were included in the study and divided into 2 groups: group 1-hyperprolactinaemia without pituitary adenoma (n=26) and group 2-hyperprolactinaemia with pituitary adenoma (n=113). Of 113 patients in group 2, 60 had microadenoma and 53 had macroadenoma. Results. The results show that with prolactinaemia levels above 349 ng/ml, the odds of detecting pituitary macroadenoma increases significantly, while the odds of detecting microadenoma decreases. Statistical analysis revealed that the odds ratio for microadenoma was 0.597 and for macroadenoma was 1.674, but neither value reached statistical significance. This data emphasis the importance of considering the level of prolactinaemia in the diagnosis of pituitary adenomas. Conclusions. Prolactinaemia levels of 349 ng/ml’ were characteristic of pituitary macroadenoma as evidenced by a statistically significant (p<0.05) microprolactinoma odds ratio value of 76.957 (95% CI 9.909; 597.687) with an odds ratio value for macroprolactinoma of 0.013 (95% CI 0.002; 0.101).
Keywords: hyperprolactinemia, prolactinoma, pituitary adenoma, odds ratio

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