SUMMARY
The article presents the results of determining the level of markers of endothelial dysfunction in patients with coronary heart disease (CHD) with arterial hypertension (AH) before and after coronary artery bypass grafting (CABG) in the near term. 50 patients with CHD and AH were examined, divided into two groups: group I, 30 patients with CHD and AH who underwent CABG, group II, 20 patients with CHD and AH who did not undergo CABG. Clinical examination included clarification of complaints, collection of anamnesis, physical examination, ECG, echocardiography. Concentrations of endothelin-1 (ET-1) and nitric oxide (NO) were determined in the blood. The concentration of ET-1 in group I patients 12 months after CABG decreased by 28.4% compared to the baseline (t=1.84, p=0.071). In patients of group II, an increase in the concentration of ET-1 was noted after 12 months compared with the baseline by 18.1% (t=1.27, p=0.213). The ET-1 index in group I after 12 months was 43.0% lower than in group II (t=3.14, p=0.003). The blood content of the NO metabolite in group I patients after CABG increased by 21.7% compared with the baseline (t=2.05, p=0.044). The concentration of NO after 12 months in group I patients exceeded that in group II patients by 27.1% (t=2.68, p=0.010). Thus, in patients with coronary artery disease with arterial hypertension after coronary artery bypass grafting in the early postoperative period after 12 months, there is a significant improvement in endothelial function, which is expressed by a decrease in endothelin-1 and an increase in nitric oxide. The results of this study can be used to optimize the conservative treatment of coronary heart disease in patients after CABG for the prevention of complications.
Keywords: coronary heart disease, arterial hypertension, endothelial dysfunction, coronary artery bypass grafting, endothelin-1, nitric oxide

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