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THE ROLE OF HORMONAL RECEPTORS IN THE OCCURRENCE OF METASTASES TO THE AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER
Akhundova J.N., Gasimov N.V., Soltanova M.J.


DOI: 10.61775/2413-3302.v1i35.03


SUMMARY
Were studied the as well as the relationship between ultrasound parameters of the tumor and lymph nodes and clinical and morphological characteristics of 184 women with breast cancer (BC) aged 22-75 years, and the level of ER, PR, HER2 and Ki67 receptors on the tumor surface. According to the results of immunohistochemical analysis of the tumor, 142 (77.2%) patients with breast cancer had estrogen receptors (ER+), 115 (62.5%) patients had progesterone receptors (PR+), 41 (22.3%) patients - progesterone receptors (PR+). HER receptors (HER2+) were detected in 137 (74.5%) patients, and the level of Ki67 expression in tumor tissue was higher than 14 (Ki67≥14). It has been established that ER+ tumors are predominantly detected in patients with a G2 differentiation degree and more often metastasize to the bone. Patients with HER2+ tumors have fewer axillary lymph node metastases, especially subclavian lymph nodes, compared with HER2 patients, and have a high metastatic capacity, predominantly to the lungs. In these patients, the shape of metastatic axillary lymph nodes is more spherical, and the level of ER+ and PR+ receptors is low. In patients with Ki67≥14, tumors with a radial contour statistically significantly predominate; a small number of metastases were recorded in the axillary lymph nodes, especially in the supraclavicular lymph nodes. In patients with HER2+ and Ki67≥14, more serious disturbances in the clinical and morphological features of the axillary lymph nodes are observed.
Keywords: breast cancer, ultrasound examination, hormonal receptors, lymph nodes


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