Rzakuliyeva L.M., Aslanova R.A.
PERINATAL OUTCOMES AFTER IN VITRO FERTILIZATION
Abstract: The article presents a literature review reflecting the issues of perinatal outcomes after in vitro fertilization. A systematic search of the scientific literature was conducted in the PubMed/MEDLINE, EMBASE, COCHRANE and eLIBRARY databases to identify studies on this issue (using the key phrases “assisted reproductive technologies”, “in vitro fertilization”, “perinatal outcomes”).
Keywords: assisted reproductive technologies, in vitro fertilization, perinatal outcomes, newborns
Mehraliev O.Sh.
PREVALENCE OF ARRHYTHMIAS IN THE GENERAL POPULATION AND IN HIGH-RISK GROUPS
Abstract: The article shows, based on various literature sources, that the frequency and clinical types of arrhythmias are different in different countries.Data obtained in numerous studies on the prevalence of arrhythmias are very contradictory and depend both on the characteristics of populations and on methodological approaches, which requires further epidemiological studies. An increase in the duration of ECG recording leads to an increase in arrhythmias frequency. Very heterogeneous results of the performed studies, as well as data about the high clinical significance of individual CRDs.
Keywords: cardiac arrhythmias, atrial fibrillation, electrocardiogram, Holter monitoring
Khaitov K.N., Abidov Kh.A., Abidov A.M., Karimov B.B., Umarov Yo.M., Yunusova Kh.R.
CLINICAL FEATURES OF ATOPIC DERMATITIS IN CHILDREN
Abstract: The article provides a nuanced exploration of the distinctive clinical characteristics associated with atopic dermatitis in the pediatric population. The article encapsulates a comprehensive overview of the clinical landscape, highlighting key aspects that contribute to a deeper understanding of this prevalent skin condition in children. The article thoroughly addresses the primary clinical manifestations of atopic dermatitis, including pruritus, erythema, and the characteristic distribution pattern of skin lesions. The author's meticulous examination extends beyond the surface, delving into the age-dependent variations in symptomatology, offering valuable insights into how the presentation of atopic dermatitis evolves from infancy to adolescence. Additionally, the article explores the interconnectedness between atopic dermatitis and other allergic conditions, illuminating the intricate relationships that underlie the broader spectrum of pediatric allergic sensitivities. Grounded in up-to-date research findings and clinical observations, this annotated article emerges as an indispensable resource for healthcare professionals, researchers, and individuals seeking a comprehensive grasp of the clinical nuances associated with atopic dermatitis in children. It not only serves as an study tool but also contributes to the ongoing discourse on effective diagnosis, management, and potential avenues for future research in this critical area of pediatric dermatology.
Keywords: atopic dermatitis, childhood, clinical features, rashes, SCORAD, dermatology
Nazarova G.E.
THE ROLE OF ENDOCRINOLOGICAL FACTORS IN IDIOPATHIC MALE INFERTILITY
Abstract: Hormonal imbalance plays an important role in the etiology of idiopathic male infertility. The purpose of the study is to study the concentration of certain hormones (follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and prolactin) in the blood serum of individuals with idiopathic male infertility. For this purpose, blood and sperm samples from 101 people aged 20-46 years with idiopathic male infertility were analyzed. During the research study, the concentration of FSH in the blood of men with asthenozoospermia was increased by 57.7%, in men with oligozoospermia by 2.4 times, in men with non-obstructive azoospermia by 8.8 times, in men with obstructive azoospermia by 2.1 times compared with control. There was observed an increase in LH concentration by 39.3% in men with oligozoospermia and by 2.9 times in men with non-obstructive azoospermia. Prolactin concentration was significantly increased by 89.0% in men with non-obstructive azoospermia. Although testosterone concentrations did not change significantly in the study groups, there was a downward trend in men with non-obstructive azoospermia. A significant increase in the concentration of FSH (4.2 times) and LH (2.2 times) was determined in men with non-obstructive azoospermia compared to men with obstructive azoospermia. Thus, in idiopathic male infertility, a serious hormonal imbalance has been identified, this imbalance was more pronounced in patients with non-obstructive azoospermia.
Keywords: male infertility, follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin
Shukurov R.T.
METHODS OF SYNTHESIS AND QUALITY DETERMINATION OF 177Lu-DOTA-TATE RADİOPHARMACEUTİCALS
Abstract: In the article are presented for the first time in the region, the results of researches on the development of methods of synthesis and quality determination of the 177Lu-DOTA-TATE radiopharmaceuticals, in the Nuclear Medicine and Radionuclide Therapy department of the National Oncology Center in our country, which is applied in the targeted radionuclide treatment of neuroendocrine tumors. Based on the proposed conditions, the synthesis of the radiopharmaceuticals was successfully applied in the existing production facility. The synthesis process was accompanied by a high yield. At the same time, based on the positive results of the modern analysis methods applied to determine the quality of the studied radiopharmaceuticals, it was concluded that the radiopharmaceuticals can be used in clinical practice in the treatment of neuroendocrine tumors in a reliable and safe manner.
Keywords: Radiopharmaceuticals, 177Lu-DOTA-TATE, TLC, HPLC
Aliyeva G.R., Akhundova I.M., Kerimova K.M., Hajiyeva R.S., Aliyea G.F.
RELATIONSHIP OF SOME HEMOSTASIS PARAMETERS WITH EXTERNAL RESPIRATORY FUNCTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Abstract: The article studied the relationship of some indicators of hemostasis with the external respiratory function (ERF) in chronic obstructive pulmonary disease (COPD) and the effect of prescribing anticoagulants and antiaggregants along with basic therapy on the clinical and functional course of the illness on clinical, laboratory and functional materials of 132 patients. No significant correlation was found between FEV1 and platelet count, thrombocytocrit, blood clotting, prothrombin index, and fibrinogen (0˂r˂0,2). There was a significant (p<0.05) weak negative correlation between the FEV1 index and the number of red blood cells, hemoglobin, and hematocrit (-0,304˂r˂-0,173). The use of anticoagulants and antiaggregants does not significantly affect the parameters of ERF, but contributes to a decrease in hospitalization days of patients with COPD (p<0.05).
Keywords: chronic obstructive pulmonary disease (COPD), hemostasis, external respiratory function (ERF)
Mammadbayli A.K., Mursalova U.G.
DEPENDENCE OF INTRACRANIAL NON-TRAUMATIC HEMORRHAGES ON MATERNAL AGE AND NEWBORN BODY WEIGHT
Abstract: The aim. To assess the dependence of the risk of intracranial non-traumatic hemorrhages on the age of the mother and the body weight of the newborn. Materials and methods of research. A prospective study was conducted at the Republican Perinatal Center, a comprehensive neurological examination and neurosonography was carried out on all newborns (996). The studied population was divided into groups: children with and without intracranial non-traumatic hemorrhages, as well as those who died in the perinatal period due to this pathology. These groups were compared according to the structure of maternal age, serial numbers of births, gestational age, body weight, sex of newborns and methods of delivery. Subgroups by maternal age were distributed according to the body weight of newborns and the frequency in these subgroups was determined. To level the role of fetal weight, standardization was carried out. Standardized rates of nontraumatic intracranial hemorrhage were compared in each maternal age group. Results. The actual and standardized incidence of intracranial non-traumatic hemorrhage was 11.7 and 16.6% at the age of 20 years, 12.1 and 14.7% at the age of 20-24 years, 14.5 and 14.6% at the age of 25-29 years, 13.2 and 12.9% at the age of 30-34 years, 32.1 and 24.8% at the age of 35 years and older. Conclusions. Maternal age under 20 years, 35 years and older is an independent risk factor for intracranial non-traumatic hemorrhages in newborns.
Keywords: intracranial non-traumatic hemorrhage, maternal age, body weight, newborn
Isgandar M.A
INFLUENCE OF THE BLOOD PRESSURE RANGE "130/80-139/89 mm Hg" ON THE VALUE OF CARDIOVASCULAR RISK IN INDIVIDUALS WITH NORMAL GLUCOSE METABOLISM
Abstract: The aim of this study is to evaluate the effect of the blood pressure range "130/80-139/89 mm Hg" on cardiovascular risk in individuals with normal carbohydrate metabolism. A retrospective analysis was carried out based on outpatient records of 597 patients in the archives of the Azerbaijan Association of Endocrinology, Diabetology and Therapeutic Instructions, as well as in individuals with normal carbohydrate metabolism, diagnostic criteria for arterial hypertension ACC/AHA (2017) and ESC/ESH (2018) were used and for cardiovascular risk assessment calculators such as PROCAM Framigham Risk Score based on lipid profile, Framigham Risk Score based on body mass index, QRISK 2, ASCVD, Pooled Cohort Equations. Increase in systolic blood pressure by 130-139 mm Hg. Art. and/or diastolic blood pressure by 80-89 mm Hg. Art. Resulted in increased cardiovascular risk in individuals with normal carbohydrate metabolism when using cardiovascular risk calculators, either alone or in combination. A further increase in blood pressure increases this risk.
Keywords: normal carbohydrate metabolism, arterial hypertension, cardiovascular risk, cardiovascular diseases
Gafarov T.A., Hagverdi E.R.
THE EFFECT OF LONG-TERM PSYCHOGENICS ON THE DYNAMICS OF INPATIENT TREATMENT OF PATIENTS WITH SCHIZOPHRENIA
Abstract: The article is devoted to the study of the impact of protracted psychogenic factors on the dynamics of inpatient treatment of patients with schizophrenia. This issue is important for understanding the relationship between endogenous and exogenous factors in the development and treatment of the schizophrenic process, which has long been a key issue in psychiatry. The study material was 82 patients suffering from schizophrenia, who were refugees and internally displaced persons from their places of permanent residence, abandoned by them as a result of the Karabakh conflict, which in this context is still a unique psychopathogenic situation. A generalized assessment of the dynamics of inpatient treatment of patients with schizophrenia of the main group (refugees and internally displaced persons) gives reason to believe that it is determined not only by the clinical and dynamic features of the schizophrenic process, but also by other factors, both psychogenically determined and environmental, family and others that require further clarification.
Keywords: schizophrenia, Karabakh conflict, refugees, protracted psychopathogenic situation, dynamics of inpatient treatment
Shadlinski V.B., Abdullayev A.S.
CHARACTERISTICS OF MASTOID FORAMEN VARIATIONS IN GENDER IN I AND II ADULTHOOD
Abstract: The aim of the study was to investigate the variants of mastoid foramen in gender aspects in I and II adulthood. Materials and methods of the study. 28 male and 40 female skulls of I adulthood and 34 male and 38 female skulls of II adulthood were used in the study. Results. Studies of male and female I adulthood skulls showed that for the left and right mastoid foramen, the difference was not statistically significant (Pχ2=0,865 and Pχ2=0,317). Applying the Mann-Whitney U test in adulthood, the difference was also found to be statistically insignificant (for the left mastoid foramen, PU=0,936 and for the right mastoid foramen, PU=0,291). In II adulthood, the difference in data obtained for the left and right mastoid foramen were not statistically significant (for the left mastoid foramen, Pχ2=0,517 and for the right mastoid foramen, Pχ2=0,993). Mann-Whitney U test also revealed that the difference was not statistically significant (for the left mastoid foramen, PU=0,306 and for the right mastoid foramen, PU=0,769). Conclusion. Evaluation of mastoid foramen variants in age and gender serves the interests of clinical practice and leads to the reduction of risky situations in surgical interventions.
Keywords: mastoid foramen, I adulthood, II adulthood, male skulls, female skulls, occipitomastoid suture
Salimova N.A.
DIAGNOSTIC OPPORTUNITIES FOR INVESTIGATING PLEURAL FLUID IN EXUDATIVE PLEURITIS OF TUBERCULOSIS ETIOLOGY
Abstract: Despite the fact that exudative pleurisy of tubercular origin is characterized by significant changes in the biochemical status of blood and pleural exudate, these changes in most cases are non-specific, and the analysis of literature data leads to the conclusion that the diagnosis and differential diagnosis of pleurisy of various origins are still relevant and remains unresolved. It is important to conduct a comprehensive comparative analysis of laboratory methods to determine diagnostic capabilities and their effectiveness.
Keywords: tuberculosis, exudative pleurisy, diagnostics
Kurbanova N.F, Abdiyeva Y.D, Maharramova S.M.
DIAGNOSIS AND TREATMENT OF "DRY EYE" SYNDROME IN PATIENTS WITH OPEN-ANGLE GLAUCOMA
Abstract: The aim of the work was to study the frequency of occurrence of dry eye syndrome (DES) in a group of patients with open-angle glaucoma during outpatient observation and to develop a treatment strategy. Clinical and functional changes in the ocular surface were studied in 60 patients with primary open-angle glaucoma (POAG) with a disease experience of 3-5 years. For the study, 2 study groups of patients similar in gender and age were formed. The study showed that it is important to use antihypertensive drugs with a reduced content of a preservative or without it. Timely prescribe tear replacement therapy and lubricants to patients. Preference is given to combined antihypertensive drugs.
Keywords: glaucoma, dry eye syndrome, hypotensive drugs
Alimova D.D.
STEP-BASED TREATMENT AND DIAGNOSTIC ALGORITHM FOR DIFFERENT PHENOTYPES OF POLYPOUS RHINOSINUSITIS
Abstract: In recent years, there has been a noticeable increase in the proportion of polypous rhinosinusitis in the structure of diseases of the nasal cavity and paranasal sinuses, which is due to a number of factors: changes in the environmental situation, an increase in the number of bacterial, viral and occupational pathogenic agents. The use of combination treatment regimens using topical and systemic corticosteroids to date shows encouraging results, but requires further standardization regarding the choice of drugs and their duration of administration, and safety monitoring. The purpose of this study was to improve methods of diagnosis and treatment of patients with polyposis rhinosinusitis.
Keywords: polypous rhinosinusitis, clinical research methods, functional endoscopic sinus surgery
Mammadov I.I.
THE OUTCOMES OF THE TREATMENT OF PATIENTS WITH DIVERTICULAR BLEEDING
Abstract: The outcomes of the treatment of 13 patients with diverticular bleeding were analyzed. Due to inflammation around diverticula the endoscopic hemostasis hasn’t given sufficient effect. The recurrence bleeding rate was 38,5% after first, and 40% after second attempt. 1 patient died after emergency surgery, due to 3rd recurrence of bleeding. Inflammation and anticoagulant drugs were evaluated as risk factors for recurrence bleeding. However, overweight and chronic kidney diseases were the risk factors, which has a negative impact to the outcomes of the treatment.
Keywords: diverticular, bleeding, endoscopic hemostasis, recurrence
Kazimova A.U., Guseynova G.A., Polukhova Sh.M., Majidova U.M., Abdullayeva R.M.
STUDY OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON ESTRADIOL CONCENTRATIONS IN BLOOD PLASMA
Abstract: In presented article the effect of long-term intake of calcium antagonists on the concentration of estradiol in the blood was studied. The studies were carried out on 82 female white rats, grown in laboratory conditions, weighing 180-230 grams, which have reached puberty at the Scientific Research Center of the Azerbaijan Medical University. Verapamil 5, 25 mg/kg (Isoptin, Abbot Laboratories S.A., Italy), nifedipine 5, 10 mg/kg (Farmadipin, Farmak Ukraine), diltiazem 5, 20 mg/kg (Diltizem-L, MNIS-Istanbul) were used in the research. The concentration of estradiol in blood plasma was determined by enzyme immunoassay using the BioScreen MS-500 device. Blood was taken from the hearts of experimental animals under ether anesthesia. To determine the concentration of the hormone estradiol in the blood, a set of reagents "Eliza Kit Estradiol" was used. Estradiol levels were 3.9% lower and 40.4% higher with verapamil (5 mg/kg) compared with control females in females receiving long-term treatment with nifedipine at a dose of 5 mg/kg. With long-term use of diltiazem at a dose of 5 mg/kg, the concentration of estradiol differed by 3.3% (p>0.05). With a corresponding increase in doses, nifedipine 10 mg/kg (65.0±2.4) > diltiazem 20 mg/kg (39.3±0.7) > verapamil 25 mg/kg (34.3±0.7) increased the concentration estradiol.
Keywords: calcium antagonists, pregnancy, estradiol, reproductive function
Guliyev F.A., Nazirova V.B., Gafarov I.A.
POLYMORPHISMS OF INTEGRIN AND FIBRINOGEN GENES IN DIFFERENT PHENOTYPES OF ARTERIAL HYPERTENSION
Abstract: Introduction. Cardiovascular diseases are the leading cause of death and disability in most countries, including Azerbaijan. Genetic factors play an important role in susceptibility to coronary heart disease, and up to 40-60% of cases may be due to heredity. Materials and methods. A total of 100 patients were examined, of which 76 had hypertension, 24 formed the control group. The examination of patients included the collection of anamnesis, anthropometric indicators, instrumental, laboratory and genetic studies. The genes of integrins B3 and A2, as well as fibrinogen, were determined by the MassARRAY method. Research results. Gene polymorphisms such as ITGA2 and ITGB3 are associated with an increased risk of thrombotic diseases. Additionally, polymorphisms in the ITGB3 gene, which encodes GPIIIa, are associated with changes in the shape of the beta-3 subunit and increased fibrinogen binding. Different genotypes of the ITGA2, ITGB3 and FGB genes are associated with various aspects of cardiovascular pathology, including dyslipidemia, left ventricular septal hypertrophy and left ventricular diastolic dysfunction.
Keywords: arterial hypertension, genotype, polymorphism, coronary heart disease
Isayev J.P., Mammadova H.H., Taghiyeva N.J.
COQNITIVE AND ASTHENIC IMPAIRMENTS AFTER COVID-19
Abstract: COVID-19 infection often causes a number of persistent neurological complications, the most common of which are cognitive and asthenic symptoms. The article provides information about the frequency and clinical characteristics of these symptoms after the infection with COVID-19, the dependence of their manifestation on the severity of the disease, its clinical significance and the impact on the patient's lifestyle. Mechanisms of development of cognitive and asthenic symptoms during COVID-19 infection are discussed. Including the direct effect of the causative virus on the brain substance, the role of immune-metabolic disorders caused by coronavirus, cerebral hypoxia and cerebrovascular diseases are investigated. The effect of antiplatelet therapy prescribed to prevent recurrent ischemic events in patients with cardiovascular diseases on the course and neurological complications of COVID-19 is analyzed. The role of these factors, including cerebral hypoxia, social isolation of quarantine-related patients, and decompensation of accompanying diseases in the emergence of asthenic symptoms and cognitive disorders is analyzed. The article also deals with prevention and treatment of neurological complications of coronavirus infection. At the same time, a clinical observation of persistent and severe cognitive impairment in a patient with a moderately severe form of COVID-19 infection is presented.
Keywords: COVID infection, post-COVID syndrome, cognitive impairment, asthenia, cerebrovascular diseases
Isayev J.P., Mammadova H.H., Taghiyeva N.J.
KAWASAKI DISEASE (American College of Rheumatology (ACR)/Vasculitis Foundation (VF) Clinical Guidelines (2021))
Abstract: Are presented the current provisions of the recommendations of the American College of Rheumatology (2021) on Kawasaki disease – a systemic vasculitis affecting small and medium-sized vessels and occurring mainly in children under 5 years of age. The existing diagnostic and treatment algorithms are covered to prevent the progression of the disease and damage to internal organs.
Keywords: Kawasaki disease, recommendations, diagnosis, treatment algorithms
Javadzade V.N.
ABOUT SEN AND TTV INFECTIONS
Abstract: The article diseasses SEN and TTV infections. İnformation is provaded about etiology, epidemiology, clinical and diagnosis principles of SEN and TTV infections. Pathogenesis and pathological anatomies of diseases haven`t fullu studied yet. But scientific-research works is continues. For speafic diagnosis is used Polymerase Ring Reaction (PCR). There aren`t speaific antiviral medicines against the causotiae agents of the disease, a vaccine againest infections has not developed.
Keywords: virus, genotype, clinic, hepatitis, diagnosis, treatment
Mehdi Məmmədbağır oğlu Quliyev – 100
ANNIVERSARY
Namazov N.C.
100 YEARS OF DEVELOPMENT OF THE SCIENCE OF MEDICAL ENTOMOLOGY IN AZERBAIJAN: CHALLENGES AND SCIENTIFIC ACHIEVEMENTS
