SUMMARY
Background. Chronic generalized periodontitis (CGP) is associated with dysregulation of inflammatory and immune responses. In patients with concomitant food allergy, Th2-mediated immune mechanisms may contribute to increased severity of periodontal inflammation. Objective. To evaluate cytokine profile alterations and their relationship with allergic inflammation markers in patients with chronic generalized periodontitis associated with food allergy. Material and methods. Clinical and immunological assessment of patients with CGP was performed, including evaluation of cytokine levels and total IgE concentration. Comparative analysis was carried out between patients with isolated CGP and patients with CGP associated with food allergy. Results. The study demonstrated a pronounced imbalance of cytokine regulation in patients with CGP, reflecting activation of inflammatory and immune responses. Patients with combined CGP and food allergy showed significantly elevated IL-4 and total IgE levels, indicating involvement of Th2-mediated immune mechanisms and enhancement of the allergic inflammatory component. A positive correlation between IL-4 and IgE levels confirmed the relationship between systemic allergic reactivity and severity of inflammatory-destructive periodontal changes. Conclusion. The obtained findings highlight the importance of immune-inflammatory mechanisms in the pathogenesis of CGP associated with food allergy and support the need for an integrated diagnostic and therapeutic approach in patients with periodontal diseases and concomitant allergic disorders.
Keywords: chronic periodontitis, food allergy, blood, cytokines, total IgE

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