SUMMARY
Objective. To evaluate the association between serum amylin and osteocalcin levels and bone mineral density parameters in women with early menopause and densitometrically (DXA) confirmed osteoporosis. Materials and Methods. A total of 37 women with early menopause aged 18–46 years (mean age 35.11±9.29 years) were examined. All patients underwent blood testing for parathyroid hormone (PTH), osteocalcin, and amylin levels, as well as ultrasound bone densitometry. The calcaneus was used as the study site. The following parameters were assessed: SOS, BUA, BQI, and T- and Z-scores. Results and Discussion. In 18.9% of patients, the T-score ranged from –0.8 to –0.9 (borderline value). In 67.6% of patients, the T-score ranged from –1 to –2.3 (osteopenia), and in 13.5% of patients it varied from –2.6 to –3.0 (osteoporosis). The amylin level was 29.35 pmol/L in the borderline group, 33.36 pmol/L in the osteopenia group, and 26.39 pmol/L in the osteoporosis group. Osteocalcin levels were 17.13 ng/mL in women with borderline values, 24.53 ng/mL in osteopenia, and 21.43 ng/mL in osteoporosis. A correlation was found between amylin and SOS (r=0.501, P<0.01), and between amylin and BUA (r=–0.719, P<0.001). Osteocalcin correlated with BUA (r=–0.838, P<0.001) and with the Z-score (r=0.660, P<0.001). Conclusion. In our sample, amylin appears to be a more sensitive marker of impaired bone metabolism in women with early menopause. Its levels reflect both the compensatory activation of bone remodeling at the stage of osteopenia and the depletion of regulatory mechanisms in established osteoporosis. Osteocalcin demonstrates only a tendency toward reduction in severe osteoporosis, whereas amylin more clearly differentiates the stages of deterioration in bone quality. Further studies are required to determine the most informative hormonal marker of bone destruction in patients with confirmed osteoporosis, as amylin or osteocalcin deficiency may serve as a predictor of bone loss and contribute to the development of osteoporosis.
Keywords: early menopause, osteocalcin, amylin, ultrasound densitometry, osteopenia, osteoporosis

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