SUMMARY
Goal. To study the comparative influence of representatives of different chemical groups of CA on histomorphological changes in the ovaries of female white rats. Material and methods. The control group was administered 0.2 ml of 0.9% NaCl solution daily, the experimental animals were administered verapamil at a dose of 5 mg/kg and 25 mg/kg, nifedipine at a dose of 5 mg/kg and 10 mg/kg, and diltiazem at a dose of 5 mg/kg and 20 mg/kg. After 21 days, the animals were decapitated, ovaries were removed and were fixed in 10% formalin solution, were clarified in xylene, paraffinized and formed into blocks. Sections of 5 microns thickness were prepared from the blocks using a microtome (Leica RM 2125 RTS, Germany). Sections were stained with hematoxylin and eosin (Merck, Germany). The preparations were examined under a light microscope (Leica DM 750, Germany). Changes were recorded using a camera attached to the microscope (Leica ICC 50, Germany). Results. Verapamil at a dose of 5 mg/kg, the number of preantral follicles was (2.3±0.4), which is 16.7% (p>0.05) less compared to the control group. The number of antral follicles was (7.4 ± 0.6), which is 42% less (p < 0.05). In the group of nifedipine (5 mg / kg), the quantitative indices of antral and preantral follicles decreased by 28.5% and 21%, respectively. In the group receiving nifedipine (10 mg/kg), this reduction was 71% compared to the control group and was 16.7% higher than in the group receiving verapamil (p>0.05). In females receiving diltiazem (20 mg/kg), the number of preantral follicles decreased by 41.7% compared to the control group (p>0.05). Conclusion. Has been founded potential negative impact of verapamil, as well as diltiazem, on the ovaries, and when high doses are required, the advantage of the nifedipine in this aspect has been determined.
Keywords: calcium channel blockers, antireproductive effect, ovary, follicle

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