SUMMARY
Cardiovascular diseases (CVDs), particularly ischemic heart disease and ischemic stroke, remain major global health challenges, contributing significantly to mortality and disability. Recent advances in molecular genetics, including Genome-Wide Association Studies (GWAS), have identified genetic factors that influence CVD susceptibility. A key marker is the fibrinogen gene (FGB), with polymorphisms like G (-455) A linked to increased fibrinogen levels, a major risk factor for thrombosis and CVD. Studies have shown that the FGB-455G/A polymorphism is associated with higher risks of ischemic heart disease and stroke, especially in Asian populations. Understanding these genetic markers enables early identification of high-risk individuals, paving the way for personalized prevention and treatment strategies. Overall, genetic insights into CVDs offer new opportunities for targeted interventions to reduce disease incidence and improve outcomes.
Keywords: cardiovascular diseases, gene, polymorphism, fibrinogen

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