SUMMARY
The aim of the study was a comparative histomorphological evaluation of the results of laser-technological treatment of patients with varicose veins of the lower extremities. The study planned to examine the effectiveness of the combined use of endovascular laser ablation (EVLA), Venocoryl ointment and low-intensity laser beams in the treatment of trophic wounds caused by varicose veins of the lower extremities, as well as morphological changes in the skin and subcutaneous tissue in the ulcer area. Patients were randomized into 3 groups of 25 patients each: Group I – EVLA and mini-phlebectomy were performed together. Group II – EVLA, Venocoryl ointment and low-intensity laser beams were used in complex treatment. Group III – EVLA, miniphlebectomy and Venocoryl ointment were prescribed together for treatment. During the experiment, the morphological changes recorded in different groups were mostly identical and their dynamics were parallel. During this period, many morphological parameters representing tissue damage disappeared, especially in biopsies taken on the 7th day. Based on the above indicators, it can be said that in dynamic observation, the combined application of EVLA, Venocoryl ointment and low-intensity laser beams in the main group has almost the same effect as other treatment methods, but the faster reduction of thrombi in the microcirculation in the main group allows us to say that this organization of treatment provides earlier restoration of microcirculatory circulation. Therefore, it can be successfully applied in the treatment of varicose veins as an alternative treatment plan.
Keywords: mathematical model, mycoses, random variables, time series, trend line, biostatistics methods

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REFERENCES

1. Самарский А.А, Михайлов А.П. Математическое моделирование: Идеи. Методы. Примеры. М.: Физмат, 2005, -320 с.
2. Бакин А.Н., Хрипков С.Ю.Математическое моделирование динамики риска инфекционного заболевания // Проблемы риска. Т.6, 2009, №2, с.24-31
3. Карякина О.Е. и др. Применение математических моделей в клинической практике // Экология человека. 2012, 7. С.103-106.
4. Абдуллаева Г.Г., Шахинташ А., Имранов Ф.Б. Система диагностики функционального состояния гомеостаза в токсикологии (на примере укуса гюрзы) // Журнал вычислительной и прикладной математики, Киев, 2011, №3 (106).
5. Юнкеров В.И., Григорьев С.Г. Математико-статистическая обработка данных медицинских исследований. Санкт-Петербург, 2002, 212 c.
6. Гурьева В.М., Котов Ю.Б.. Анализ коротких отрезков временных рядов в медицинских задачах // ИПМ им. М.В.Келдыша РА Н, Москва, 2005. Работа выполнена при финансовой поддержке Российского фонда фундаментальных исследований (проект № 04-01-00434).
7. Елисеева И.И., Юзбашев М.М. Общая теория статистики: учебник для вузов. Москва: Финансы и статистика, 2009. 656 с.