| AZ | EN | RU

STATİSTİKA


TAKSİFOLİN TİBBİ PRAKTİKADA
Babayeva M.Y., Hüseynova G.A., Kazımova A.U.

DOI: 10.61775/2413-3302.v2i36.03

XÜLASƏ
Məqalədə müxtəlif xəstəliklərin qarşısının alınması və müalicəsində mühüm rol oynayan Taxifolin haqqında məlumat verilir. Tədqiqatlar Taxifolinin geniş farmakoloji fəaliyyətini ortaya qoydu: antioksidant, iltihab əleyhinə, hepatoprotektiv, antiangiogenik xüsusiyyətlər, antidiabetik, kardioprotektiv, neyroprotektiv və s. Beyin sapında infeksiya və iltihab reaksiyasına cavabdeh olan fermentləri inhibə edərək, Taxifolin həm də Alzheimer xəstəliyinə qarşı fəaliyyətini dəstəkləyən neyroprotektiv rol oynayır. Taxifolinin əla antioksidant fəaliyyəti sübut edilmişdir ki, o, lipidlərin peroksidləşməsinin qarşısını alır, H2O2 ilə poli(ADP-riboza) polimerazanın parçalanmasına səbəb olur.
Açar sözlər: Taksifolin, flavonoid, antioksidant aktivlik, oksidləşdirici stress

ƏDƏBİYYAT
  1. Ahmadi A., Shadboorestan A., Nabavi S. The role of hesperidin in cell signal transduction pathway for the prevention or treatment of cancer // Current medicinal chemistry. 2015; 22(30):3462-71.
  2. Mahomoodally M., Gurib-Fakim A., Subratty A. Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius // Pharmaceutical biology. 2005;43(3):237-42.
  3. Heim K., Tagliaferro A., Bobilya D. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships // The Journal of nutritional biochemistry. 2002;13(10):572-84.
  4. Godos J., Castellano S., Ray S. et al. Dietary polyphenol intake and depression: Results from the mediterranean healthy eating, lifestyle and aging (meal) study // Molecules. 2018;23(5):999.
  5. Beecher G. Overview of dietary flavonoids: nomenclature, occurrence and intake // The Journal of nutrition. 2003;133(10):3248S-54S.
  6. Sroka Z., Cisowski W. Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids // Food and Chemical Toxicology. 2003;41(6):753-8.
  7. Topal F., Nar M., Gocer H. et al. Antioxidant activity of taxifolin: an activity–structure relationship // Journal of enzyme inhibition and medicinal chemistry. 2016;31(4):674-83.
  8. Ribeiro D., Fernandes E., Freitas M. Polyphenols: mechanisms of action in human health and disease! Flavonoids as modulators of neutrophils’ oxidative burst: structure-activity relationship, Polyphen. Mech. Action Hum. Polyphen Mech Action // Hum. Health Dis. 2018:261-76.
  9. Wang X., Xia H., Xing F. et al. Highly sensitive and robust UPLC–MS with electrospray ionization method for quantitation of taxifolin in rat plasma // Journal of Chromatography B. 2009;877(18-19):1778-86.
  10. Seredin S., Zherdev V., Kolyvanov G. et al. Preclinical investigation of pharmacokinetics of Dihydroquercetin // Report SU NII, Moscow. 2007.
  11. Turck D., Bresson J., Burlingame B. et al. Statement on the safety of taxifolin‐rich extract from Dahurian Larch (Larix gmelinii) // EFSA Journal. 2017;15(11):e05059.
  12. Kolhir V., Bykov V., Baginskaja A. et al. Antioxidant activity of a dihydroquercetin isolated from Larix gmelinii (Rupr.) // Phytotherapy research. 1996;10(6):478-82.
  13. Salah N., Miller N., Paganga G. et al. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants // Archives of biochemistry and biophysics. 1995;322(2):339-46.
  14. Dok-Go H., Lee K., Kim H. et al. Neuroprotective effects of antioxidative flavonoids, quercetin,(+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. Saboten // Brain research. 2003;965(1-2):130-6.
  15. Chobot V., Hadacek F., Bachmann G, Weckwerth W. Pro-and antioxidant activity of three selected flavan type flavonoids: Catechin, eriodictyol and taxifolin // International Journal of Molecular Sciences. 2016;17(12):1986.
  16. Wang Y., Wang W., Chang C. et al. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation // Journal of biomedical science. 2006;13:127-41.
  17. Cai C., Liu C., Zhao L. et al. Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo // Frontiers in pharmacology. 2018;9:1286.
  18. Zhang H., Wang Y., Yang G. et al. Taxifolin inhibits receptor activator of NF-κB ligand-induced osteoclastogenesis of human bone marrow-derived macrophages in vitro and prevents lipopolysaccharide-induced bone loss in vivo // Pharmacology. 2019;103(1-2):101-9.
  19. Tapas A., Sakarkar D., Kakde R. Flavonoids as nutraceuticals: a review // Tropical journal of Pharmaceutical research. 2008;7(3):1089-99.
  20. Yang C., Lin Y., Liu K. et al. Hepatoprotective mechanisms of taxifolin on carbon tetrachloride-induced acute liver injury in mice. Nutrients. 2019;11(11):2655.
  21. Park S., Kim H., Park H. Concurrent treatment with taxifolin and cilostazol on the lowering of β-amyloid accumulation and neurotoxicity via the suppression of P-JAK2/P-STAT3/NF-κB/BACE1 signaling pathways // PLoS One. 2016;11(12):e0168286.
  22. Saito S., Yamamoto Y., Maki T. et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy // Acta neuropathologica communications. 2017;5:1-16.
  23. Inoue T., Saito S., Tanaka M. et al. Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy // Proceedings of the National Academy of Sciences. 2019;116(20):10031-8.
  24. Rehman K., Chohan T., Waheed İ. et al. MSH. Taxifolin prevents postprandial hyperglycemia by regulating the activity of α‐amylase: Evidence from an in vivo and in silico studies // Journal of cellular biochemistry. 2019;120(1):425-38.
  25. Su H., Ruan Y., Li Y. et al. In vitro and in vivo inhibitory activity of taxifolin on three digestive enzymes // International journal of biological macromolecules. 2020;150:31-7.
  26. Itaya S., Igarashi K. Effects of taxifolin on the serum cholesterol level in rats. Bioscience, biotechnology, and biochemistry. 1992;56(9):1492-4.
  27. Igarashi K., Uchida Y., Murakami N. et al. Effect of astilbin in tea processed from leaves of engelhardtia chrysolepis., on the serum and liver lipid concentrations and on the erythrocyte and liver antioxidative enzyme activities of rats // Bioscience, biotechnology, and biochemistry. 1996;60(3):513-5.
  28. Shu Z., Yang Y., Yang L. et al. Cardioprotective effects of dihydroquercetin against ischemia reperfusion injury by inhibiting oxidative stress and endoplasmic reticulum stress-induced apoptosis via the PI3K/Akt pathway // Food & function. 2019;10(1):203-15.
  29. Tang Z., Yang C., Zuo B. et al. Taxifolin protects rat against myocardial ischemia/reperfusion injury by modulating the mitochondrial apoptosis pathway // PeerJ. 2019;7:e6383.
  30. Unver E., Tosun M., Olmez H. et al. The Effect of Taxifolin on Cisplatin‐Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation // Mediators of inflammation. 2019;2019(1):3740867.
  31. Kanwal Q., Hussain I., Latif Siddiqui H. et al. Antifungal activity of flavonoids isolated from mango (Mangifera indica L.) leaves // Natural Product Research. 2010;24(20):1907-14.
  32. Gogoi N., Chowdhury P., Goswami A. et al. Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease // Molecular diversity. 2021;25:1745-59.
  33. Kovalchuk B., Berghoff A., Karreman M. et al. Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells // Clinical & experimental metastasis. 2020;37:637-48.
  34. Lee S., Cha K., Selenge D. et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation // Biological and Pharmaceutical Bulletin. 2007;30(6):1074-9.
  35. Teselkin Y., Babenkova I., Tjukavkina N. et al. Influence of dihydroquercetin on the lipid peroxidation of mice during post‐radiation period. Phytotherapy Research // An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 1998;12(7):517-9.
  36. Kolhir V., Bykov V., Teselkin Y. et al. Use of a new antioxidant diquertin as an adjuvant in the therapy of patients with acute pneumonia. Phytotherapy Research // An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 1998;12(8):606-8.
  37. Du J., Cullen J., Buettner G. Ascorbic acid: chemistry, biology and the treatment of cancer // Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2012;1826(2):443-57.
  38. Raj U., Aier I., Varadwaj P. Taxifolin: a wonder molecule in making multiple drug targets // Ann Pharmacol Pharm. 2017;2(16):1083.